Sökning: "Lipid based formulations LBFs"

Hittade 2 uppsatser innehållade orden Lipid based formulations LBFs.

1. 1. In vitro performance prediction of LBFs using lipolysis-permeation assay with the LiDo artificial membrane: Validation and protocol optimization

   Master-uppsats, Uppsala universitet/Institutionen för farmaci

   Författare :Alaa Zangana; [2021]
   Nyckelord :;

   Sammanfattning : Lipid-based formulations (LBFs) can be an effective formulation strategy to improve the bioavailability of lipophilic drugs. However, conventional single-compartment in vitro lipolysis assays often underestimate LBF performance in vivodue to the absence of absorption sink. LÄS MER

3. 2. Effect of lipid-based formulation on the solubilization patterns if poorly water-soluble drugs.

   Master-uppsats, Uppsala universitet/Institutionen för farmaci

   Författare :Manjiri Gude; [2021]
   Nyckelord :Lipid based formulations LBFs ; poorly water-soluble drugs PWSDs ; solubility studies; coarse grained molecular dynamic simulations; solubilization; dog intestinal fluid DIF ;

   Sammanfattning : Poorly water-soluble drugs (PWSDs), to date, require advanced formulation techniques to improve solubility and achieve the required plasma concentration to show a therapeutic effect when orally administered. Lipid-based formulations (LBFs) are an enabling strategy that is being used to improve the oral delivery of PWSDs. LÄS MER