Sökning: "Pharmacokinetic Model"

Visar resultat 1 - 5 av 26 uppsatser innehållade orden Pharmacokinetic Model.

  1. 1. An Interactive MIDD Framework for Evaluation and Comparison of PBPK Model Performance

    Master-uppsats, Uppsala universitet/Institutionen för farmaci

    Författare :Dylan Garamani; [2022]
    Nyckelord :MIDD; PBPK; QSP; PK; GUI;

    Sammanfattning : Modeling and simulation are becoming indispensable elements in drug development. Mechanistic modeling is susceptible to impacting several drug development and regulatory decisions through extrapolations beyond clinically researched scenarios by using its capacity to incorporate diverse data to provide a detailed and comprehensive understanding of a physiological and biological system. LÄS MER

  3. 2. Pharmacokinetics: A comparison of physiologically based pharmacokinetic models : A comparison study

    Kandidat-uppsats, Uppsala universitet/Institutionen för farmaci

    Författare :Rosa Kafey; [2022]
    Nyckelord :PBPK; MODELLS;

    Sammanfattning : Abstract Background: This thesis explores the pharmaceutical model physiologically based pharmacokinetics (PBPK) further and focuses on the basics of parameters used for the software tools to develop new drugs on the market today. Further reflects on what drug companies place their importance on when developing a new drug and why, by focusing on 29 different drugs and the parameters provided by the PBPK-model. LÄS MER

  4. 3. Implementation of a Pharmacokinetic Model to Estimate the Contribution of Infusion Systems to the Delayed Dosing of Morphine in Children

    Master-uppsats, KTH/Medicinteknik och hälsosystem

    Författare :Karin Schaedel; [2022]
    Nyckelord :Infusion Pump; Pharmacokinetic Model; Morphine; Pediatric; MATLAB; Infusionspump; Farmakokinetisk modell; Morfin; Pediatrik; MATLAB;

    Sammanfattning : Infusion pumps administer medications like morphine to pediatric patients in order to manage pain. Drug delivery delays can be the result of flow rate variabilities in the infusion pump system. Due to the risk of over-or underdosing, this could have a high impact on the pediatric population. LÄS MER

  5. 4. Development of artificial neural networks for the prediction of outlying and influential individuals from pharmacokinetic and pharmacodynamic models

    Master-uppsats, Uppsala universitet/Institutionen för farmaci

    Författare :Osama Qutishat; [2022]
    Nyckelord :Machine learning; pharmacometrics; Neural networks; pop-pk;

    Sammanfattning : Nonlinear Mixed effect models are often used to describe population pharmacokinetics (PK) and Pharmacodynamics (PD) and play an important part of drug development both from regulatory and industry point of view. However, they can be time consuming and computationally expensive to develop. LÄS MER

  7. 5. Implementation and Evaluation of Uncertainty Estimation for Advanced Pharmacokinetic Models in DCE-MRI

    Uppsats för yrkesexamina på avancerad nivå, Umeå universitet/Institutionen för fysik

    Författare :Jonas Höglund; [2022]
    Nyckelord :;

    Sammanfattning : The goal of this report is to develop code in Python that implements and evaluates a multivariate linear error propagation for commonly used DCE-MRI models. Two pharmoacokinetic models (PK-models) were tested; modified Kety model and two-compartment exchange model. LÄS MER