Sökning: "drug delivery"

Visar resultat 1 - 5 av 103 uppsatser innehållade orden drug delivery.

  1. 1. Exploring alternative surfactants to replace PEG within lipid nanoparticles

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master); Lunds universitet/Bioteknik (CI); Lunds universitet/Bioteknik (master)

    Författare :Elina Edidovica; [2024]
    Nyckelord :Lipid nanoparticle; polyethelyne glycol PEG ; alpha-tomatine; N-hexadecyl beta d-maltoside HDM ; DOPC; DPPC; cholesterol; film hydration; stability study; DLS; Cryo-TEM; SAXS; pharmaceutical formulation; Chemistry;

    Sammanfattning : Over the past decade an increasing amount of studies has demonstrated that PEGylation not only precipitates reductions in drug delivery efficiency but also triggers the immune system to produce antibodies, specifically anti-PEG antibodies. The objective of my thesis is to explore alternative surfactants that could viably replace PEG within lipid nanoparticles. LÄS MER

  3. 2. Comparison of properties on Orally Disintegrating Tablets (ODTs) produced by direct compression or fluid bed granulation

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

    Författare :Julia Ahlbom; [2023]
    Nyckelord :Orally disintegrating tablet; fluid bed granulation; disintegration time; pharmaceutical technology; Technology and Engineering;

    Sammanfattning : Orally disintegrating tablets (ODTs) is a popular drug delivery system as they dissolve in the mouth, usually within seconds which enables easy medication for patients with problem swallowing. In this thesis properties of ODTs were compared when produced with direct compression of the excipients or the excipients were pretreated to form granules in a fluid bed granulator prior to tableting. LÄS MER

  4. 3. Development of a PNA-drug conjugate for pretargeted delivery of cytotoxic drugs

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Theranostics

    Författare :Astrid Haraldsson; [2023]
    Nyckelord :PNA; pretargeting; cancer therapy; cytotoxic payload;

    Sammanfattning : One of the major challenges in cancer treatment is delivering high enough doses of active substance specifically to cancer cells without accumulation in healthy organs. Pretargeting has emerged as a potential solution, where the delivery of a cancer recognizing (primary) agent and a cancer killing (secondary) agent are separated. LÄS MER

  5. 4. DRY POWDER FOR INHALATION - INFLUENCE OF MIXING PROCESS AND ADDITION OF MAGNESIUM STEARATE

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

    Författare :Love Ivarsson; [2023]
    Nyckelord :inhalation; drug delivery; pulmonary drug delivery; API; FPF; FPD; DD; Turbula; Diosna; mixing energy; mixing time; mixing speed; pharmaceutical technology; Medicine and Health Sciences;

    Sammanfattning : For efficient treatment of many diseases of the lung, it is beneficial to deliver the medicine to the respiratory tract directly. This ensures a rapid response since it can enter the bloodstream directly through the alveolar epithelium. Consequently, also decreases systemic effects due to the local treatment. LÄS MER

  7. 5. A novel approach for functionalising and separating Tröger's Base Analogues

    Master-uppsats, Lunds universitet/Centrum för analys och syntes

    Författare :Emil Jakobsson; [2023]
    Nyckelord :Tröger s Base; Synthesis; Chromatography; Supramolecular chemistry; Diastereomers; Organic chemistry; Chemistry;

    Sammanfattning : Tröger’s Base (TB) is a bicyclic compound containing a methanodiazocine group between two aromatic rings. The methylene bridge forces the molecule to have a bent formation; thus, the aromatic rings are close to 90 degrees relative to each other, resulting in a rigid concave aromatic cavity. LÄS MER