Sökning: "PI3K AKT"

Hittade 5 uppsatser innehållade orden PI3K AKT.

1. 1. Experimental validation of PLAC8 in small intestinal neuroendocrine tumors

   Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

   Författare :Martin Nilsson; [2023]
   Nyckelord :;

   Sammanfattning : Small intestinal neuroendocrine tumors (SI-NETs) are the most common malignant tumor in the small bowel. It is a small-growing cancer with good overall survival 5 years after diagnosis, but no full cure is available when in the metastatic stage. LÄS MER

3. 2. The effects of NOX2 and NOX4 inhibitors on panc-1 cell viability

   Kandidat-uppsats, Högskolan i Skövde/Institutionen för hälsovetenskaper

   Författare :Karl-Hermann Sielinou Kamgang; [2020]
   Nyckelord :;

   Sammanfattning : Pancreatic cancer is a leading cause of cancer related deaths worldwide and has a low survival rate 1 year after diagnosis. It is therfore important to identify new biomarkers and treatments to improve disease outcome. This experiment investigated the effects of different NOX2 and NOX4 inhibitors on Panc-1 cell lines. LÄS MER

4. 3. The effect of DLG knockout, vitamin D and probiotic treatment on Drosophila gene expression

   Kandidat-uppsats, Högskolan i Skövde/Institutionen för hälsa och lärande

   Författare :Sophie Améen; [2018]
   Nyckelord :DLG; Drosophila melanogaster; Vitamin D; Probiotics; Colorectal cancer;

   Sammanfattning : Background: Colorectal cancer is one of the most frequently diagnosed cancers today. Dlg is a tumor suppressor gene commonly silenced in cancer cells. Many colorectal cancer patients are subject to vitamin D3 deficiency and/ or an altered microbiome. LÄS MER

5. 4. Analysis of PIK3CA mutations in tumours from patients with non-small cell lung cancer using pyrosequencing

   Kandidat-uppsats, Uppsala universitet/Institutionen för kvinnors och barns hälsa

   Författare :Jennifer Jonasson; [2014]
   Nyckelord :PI3K; tumour marker; pseudogene; oncogene; targeted therapy;

   Sammanfattning : A subgroup of non-small cell lung cancer (NSCLC) cases harbour mutations in classical oncogenes, which can affect therapy response and prognosis. By therapeutically targeting the corresponding proteins with inhibitory drugs, the clinical outcome for these lung cancer patients may be improved. LÄS MER

7. 5. Protein expression analysis of PI3K/AKT pathway components in cells expressing INPP5K and MYO1C

   Master-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

   Författare :Yashar Mehrbani Azar; [2012]
   Nyckelord :PI3K AKT; INPP5K; MYO1C; Tumor Biology; Transfection; Protein expression;

   Sammanfattning : In an Experimental Rat model for endometrial carcinoma (EC) a minimal region of recurrent deletion/allelic loss at the neighborhood of the Tp53 gene has been identified. A similar observation of deletion at the homologous position on human chromosome 17 unassociated with TP53 mutation has been reported in several human cancer types. LÄS MER