Sökning: "A549"

Visar resultat 1 - 5 av 11 uppsatser innehållade ordet A549.

  1. 1. Development of a cell killing adenovirus with a novel cytotoxic transgene

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning; Uppsala universitet/Institutionen för immunologi, genetik och patologi

    Författare :Carl Blomqvist; [2023]
    Nyckelord :;

    Sammanfattning : Cancer is among the most common causes of human deaths globally. Because of limitations and adverse effects of conventional cancer treatments, the need for new treatments is imminent. LÄS MER

  3. 2. ProTargetMiner one step further : Deep comparative proteomics of Dying vs. Surviving cancer cells treated with anticancer compounds

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Analytisk kemi

    Författare :Albin Lundin; [2022]
    Nyckelord :Cancer; Surviving VS Dying; Proteomics; Comparative Proteomics; RKO; A549; MCF7; drug discovery; life; death; life and death decisions; target ranking; OPLS-DA; drug targets; novel anticancer agents;

    Sammanfattning : Cancer is a leading cause of mortality worldwide, responsible for nearly one in six deaths. Thus, there is a need for a greater understanding of cancer for the development of novel therapeutics. This master thesis project aims to compare the proteome signatures between dying and surviving cancer cells treated with diverse anticancer drugs. LÄS MER

  4. 3. Machined surfaces as designed cell culture substrates

    Master-uppsats, Lunds universitet/Industriell Produktion

    Författare :Kunal Sharma; [2021]
    Nyckelord :Surface topography; cell proliferation; cell adhesion; Technology and Engineering;

    Sammanfattning : De flesta levande celler fäster på ytor av olika slag för att kunna växa, men vilka faktorer som bidrar till deras infästning på metallytor är hittills okänt. Man vet att ytans ojämnhet spelar en roll och att vissa material är cytotoxiska. LÄS MER

  5. 4. Validation of a 3D culture model for toxicity studies in malignant and non-cancerous cells

    Master-uppsats, Lunds universitet/Institutionen för immunteknologi

    Författare :Kajsa Andreasson Dahlgren; [2021]
    Nyckelord :Dose-response; potency; in vitro; 2D model; 3D model; cancer; MEK inhibitor; trametinib; A549; LL47; Western blot; Biology and Life Sciences;

    Sammanfattning : Cancer is a widespread and commonly fatal disease in constant need of new treatments. Traditionally, new pharmaceuticals have been tested in 2D models. This is not ideal, as 2D environments do not reflect the in vivo milieu of the cells. LÄS MER

  7. 5. Semi-Supervised Learning for Cell Death Assays

    Uppsats för yrkesexamina på avancerad nivå, Umeå universitet/Institutionen för fysik

    Författare :Nelly Westman; [2021]
    Nyckelord :;

    Sammanfattning : Chemotherapy is a type of cancer treatment that uses drugs to kill the cancer cells. In order to evaluate the drug performance, we need cell death assays. Today, most cell death assays are based on fluorometric detection, which can cause phototoxic effects. LÄS MER