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Visar resultat 1 - 5 av 6 uppsatser som matchar ovanstående sökkriterier.

  1. 1. Human adenovirus type 5 infection alters mitochondrial membrane dynamics

    Master-uppsats, Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Författare :Erik Schubert; [2021]
    Nyckelord :;

    Sammanfattning : Mitochondria are double-membrane organelles that orchestrate essential cellular functions including ATP synthesis, calcium homeostasis and apoptosis. Furthermore, mitochondria are effective stimulators of the innate immune system through the release of mitochondrial components into the cytosol. LÄS MER

  3. 2. The anti-amyloidogenic chaperone DNAJB6 and its interaction with other chaperones

    Kandidat-uppsats, Lunds universitet/Matematisk statistik; Lunds universitet/Kemiska institutionen

    Författare :Gemma Nilsson; [2020]
    Nyckelord :chaperones; DNAJB6; Hsc70; Hsp110; ATP-hydrolysis; Ab42; polyQ; biochemistry; biokemi; Chemistry;

    Sammanfattning : In order to maintain proteins’ functionality their native folding state must be preserved. Chaperones fold other proteins and DNAJ-chaperones may collaborate with Hsc70 chaperones to prevent aggregation of aggregation-prone peptides such as polyQ and Aβ42, which form fibrils in currently incurable diseases as Huntington’s and Alzheimer’s, respectively. LÄS MER

  4. 3. microRNA-200 Family Expression Level Changes in Stimulated THP-1 Cells Following NLRP3 Inflammasome Activation

    Kandidat-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Kristina Backlund; [2020]
    Nyckelord :;

    Sammanfattning : Innate immunity is the immune systems rapid responses to infection after being attacked by a pathogen. Inflammatory responses are activated by the detection of pathogen-associated molecular patterns and danger-associated molecular patterns through pattern recognition receptors on inflammatory cells. LÄS MER

  5. 4. Characterization of Macrophage Activation Induced by Leukotoxin from Aggregatibacter actinomycetemcomitans 

    Uppsats för yrkesexamina på avancerad nivå, Umeå universitet/Institutionen för odontologi

    Författare :Niklas Sundling; Lisa Lü; [2018]
    Nyckelord :;

    Sammanfattning : ABSTRACT  Aggregatibacter actinomycetemcomitans (Aa), is a gram-negative, facultative anaerobe, non-motile coccobacilli colonizing the human oral cavity and is strongly associated with localized aggressive periodontitis (LAP). Aa possesses several virulence mechanisms, among others; Lipopolysaccharide (LPS), an endotoxin found in the outer membrane of Aa and Leukotoxin (LtxA), an exotoxin attached to the bacterial cell surface or in outer membrane vesicles and which has been correlating with periodontal disease mostly. LÄS MER

  7. 5. Effect of Aggregatibacter actinomycetemcomitans Leukotoxin on ATP Release through Pannexin Channels in Human Monocytes

    Uppsats för yrkesexamina på avancerad nivå, Umeå universitet/Institutionen för odontologi

    Författare :Linnéa Bäck; Frykholm Jennie; [2016]
    Nyckelord :LtxA; ATP release; Aggregatibacter actinomycetemcomitans;

    Sammanfattning : Aggregatibacter actinomycetemcomitans is strongly associated with aggressive periodontitis and one of several virulence factors is a leukotoxin (LtxA). The toxin has a consequential impact on human leukocytes which leads to an interference with the host ́s defences due to a chain reaction involving activation and release of a pro-inflammatory cytokine; interleukin-1β (IL-1β). LÄS MER