Sökning: "Frykholm Jennie"

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  1. 1. Effect of Aggregatibacter actinomycetemcomitans Leukotoxin on ATP Release through Pannexin Channels in Human Monocytes

    Uppsats för yrkesexamina på avancerad nivå, Umeå universitet/Institutionen för odontologi

    Författare :Linnéa Bäck; Frykholm Jennie; [2016]
    Nyckelord :LtxA; ATP release; Aggregatibacter actinomycetemcomitans;

    Sammanfattning : Aggregatibacter actinomycetemcomitans is strongly associated with aggressive periodontitis and one of several virulence factors is a leukotoxin (LtxA). The toxin has a consequential impact on human leukocytes which leads to an interference with the host ́s defences due to a chain reaction involving activation and release of a pro-inflammatory cytokine; interleukin-1β (IL-1β). LÄS MER