Sökning: "Drug permeation"

Visar resultat 1 - 5 av 10 uppsatser innehållade orden Drug permeation.

  1. 1. Investigating permeability characteristics of porcine esophageal mucosa: A viable ex vivo model for human buccal mucosa

    Master-uppsats, Malmö universitet/Fakulteten för hälsa och samhälle (HS)

    Författare :Renugadevi Srinivasan; [2023]
    Nyckelord :Porcine esophageal mucosa; Permeability characteristics; Drug permeation; Inter-specimen variation; Intra-specimen variation.;

    Sammanfattning : Due to its larger surface area and ease of preparation, pig esophageal mucosa has emerged as a practical and viable alternative to buccal mucosa for studying permeability characteristics in vitro. However, the permeation results in biological membranes have shown high variability due to inter-specimen and intra-specimen variations. LÄS MER

  3. 2. Development of an artificial canine colonic mucus model for drug permeation studies

    Master-uppsats, Uppsala universitet/Institutionen för farmaci

    Författare :Lingxiao Li; [2022]
    Nyckelord :;

    Sammanfattning : .... LÄS MER

  4. 3. In vitro performance prediction of LBFs using lipolysis-permeation assay with the LiDo artificial membrane: Validation and protocol optimization

    Master-uppsats, Uppsala universitet/Institutionen för farmaci

    Författare :Alaa Zangana; [2021]
    Nyckelord :;

    Sammanfattning : Lipid-based formulations (LBFs) can be an effective formulation strategy to improve the bioavailability of lipophilic drugs. However, conventional single-compartment in vitro lipolysis assays often underestimate LBF performance in vivodue to the absence of absorption sink. LÄS MER

  5. 4. Permeability of fluorescently labelled proteins in silk-based skin equivalent

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaci

    Författare :Gabriel Chumpitaz Chavez; [2021]
    Nyckelord :skin equivalent; recombinant spider silk; fibroblasts; keratinocytes; permeability; Franz cells; fluorescence; bovine serum albumin; sodium fluorescein salt;

    Sammanfattning : Development of methods for studying drug delivery systems is of great significance for the improvement of topical formulations. Active compounds for topical drug delivery are often formulated into gels and creams, that can be applied onto skin surfaces. LÄS MER

  7. 5. Models for predicting efflux transport over the blood-brain barrier

    Master-uppsats, Uppsala universitet/Institutionen för farmaci

    Författare :Marjaneh Janani; [2020]
    Nyckelord :efflux transport; brain; blood-brain-barrier; Verapamil; Risperidone; Prazosin;

    Sammanfattning : Aim: The general aim of this research is development and evaluation of novel methods for predicting active transport over the human blood-brain-barrier (BBB), while this project specifically aims to i) review the literature and select suitable methods and substrates, ii) develop models for determining in vitro kinetic properties of selected compounds, analyze the in vitro data using the developed models and to use Maximum Transport Activity (MTA) approach (Karlgren et al., 2012), iii) perform Physiology Based Pharmacokinetic (PBPK) modelling and compare to in vivo literature data. LÄS MER