Sökning: "disulphide bonds substitution"

Hittade 1 uppsats innehållade orden disulphide bonds substitution.

  1. 1. Substitution of disulphide bonds to hydrophobic amino acids in BACE1

    Master-uppsats, Institutionen för fysik, kemi och biologi

    Författare :Camilla Halvarsson; [2009]
    Nyckelord :BACE1; disulphide bonds substitution; hydrophobic amino acids; protein purification; refolding time;

    Sammanfattning : The study and understanding of Alzheimer’s disease on protein level is fundamentally important in the search for its treatment and there is a demand for proteins that can be used together with candidate drugs in crystallography trials. The refolding time reaching up to three weeks for beta-site APP cleaving enzyme 1 (BACE1), the proposed disease-generating protein, is presently not optimal and new protein constructs are needed. LÄS MER