Sökning: "endothelial cells"

Visar resultat 1 - 5 av 49 uppsatser innehållade orden endothelial cells.

  1. 1. Development and testing of in-house automatized spatial omics data analysis tool : NIPMAP (Niche-Phenotype Mapping)

    Kandidat-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Raziyeh Mohseni; [2023]
    Nyckelord :;

    Sammanfattning : The functional and anatomical characteristics of cancer cells vary among patients. Additionally, therapeutic approaches display varying responses in different individuals and cancer types due to the anatomical and functional complexity of tumor. LÄS MER

  3. 2. Design, production and in vitro evaluation of brain shuttle scFc-scFv8D3 affinity-mutants

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaci

    Författare :Jonathan Efverström; [2023]
    Nyckelord :Blood-brain barrier; In-Cell BBB-trans assay; mTfR1; Transferrin receptor; scFc-scFv8D3; Blod-hjärn barriären; mTfR1; Transferrin receptorn; scFc-scFv8D3;

    Sammanfattning : The blood brain barrier (BBB) is a challenge when developing monoclonal antibodies for neurological diseases as antibodies do not cross the BBB making brain distribution challenging. An antibody construct which binds mTfR1 to pass the BBB, scFc-scFv8D3, have previously been developed. LÄS MER

  4. 3. Molecular characterization of vascular malformations using single-cell RNA sequencing and immunohistological analysis

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Amanda Norrén; [2023]
    Nyckelord :;

    Sammanfattning : CCM is a human disease in which vascular malformations develop in the central nervous system, predominantly in the brain. The malformations which can measure up to several centimeters in size are dilated and leaky vessels, with unstable cellular junctions and thin vessel walls. LÄS MER

  5. 4. Testing Coagulation Potential of Extracellular Vesicles Derived from Aortic Stenosis Patients on Human Cardiac Spheroids

    L2-uppsats, Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Författare :Muhammad Nafiz Ikhwan Bin Nor Fuad; [2023]
    Nyckelord :Extracellular vesicles; human aortic endothelial cells; tissue factor; TNFα; coagulation pathway; cardiac spheroids;

    Sammanfattning : Cardiovascular diseases have always been the leading cause of global morbidity and mortality. Aortic stenosis, which is a kind of cardiovascular disease has a high prevalence in elderlies that are 75 years and older. Currently, the only available treatment would be valve replacement surgery. LÄS MER

  7. 5. The role of AmotL2 in the regulation of mesenchymal transitioning of endothelial cells

    Master-uppsats, Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Författare :Anita-Ann Monteiro; [2023]
    Nyckelord :Endothelial-mesenchymal transition EndMT ; atherosclerosis; transforming growth factor β TGF-β ; Angiomotin-Like 2 AmotL2 ; Scrambled Scr ; knockdown kd ; Immunofluorescence IF ;

    Sammanfattning : Background During development, endothelial cells acquire mesenchymal-like properties to migrate and facilitate normal vascular formation. This process of transformation is known as endothelial to mesenchymal transition (EndMT) and has also been implicated in diseases like vascular pathologies contributing to endothelial inflammation, atherosclerosis and tumour angiogenesis. LÄS MER