Sökning: "Blood-brain barrier"

Visar resultat 1 - 5 av 37 uppsatser innehållade orden Blood-brain barrier.

  1. 1. P-glykoprotein-mutationen - ABCB1-1Δ hos collies i Sverige

    Master-uppsats, SLU/Dept. of Anatomy, Physiology and Biochemistry

    Författare :Alice Gustafsson; [2024]
    Nyckelord :P-glykoprotein; ABCB1; ABCB1-1Δ; MDR1; collie;

    Sammanfattning : P-glykoprotein är ett effluxprotein som uttrycks på olika luminala ytor i flera organ, bland annat tarmväggen, njurtubuli, i leverns gallgångar samt i blodhjärnbarriären. Proteinet kodas av genen ABCB1 hos hund. LÄS MER

  3. 2. Design, production and in vitro evaluation of brain shuttle scFc-scFv8D3 affinity-mutants

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaci

    Författare :Jonathan Efverström; [2023]
    Nyckelord :Blood-brain barrier; In-Cell BBB-trans assay; mTfR1; Transferrin receptor; scFc-scFv8D3; Blod-hjärn barriären; mTfR1; Transferrin receptorn; scFc-scFv8D3;

    Sammanfattning : The blood brain barrier (BBB) is a challenge when developing monoclonal antibodies for neurological diseases as antibodies do not cross the BBB making brain distribution challenging. An antibody construct which binds mTfR1 to pass the BBB, scFc-scFv8D3, have previously been developed. LÄS MER

  4. 3. Design and production of adeno-associated virus vectors for imaging mitochondrial networks in the brain

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Elnaz Samadian Zad; [2023]
    Nyckelord :adeno-associated virus; mitochondria; mitochondrial networks; imaging; fluorescent protein; synapsin promoter; human embryonic kidney cells; organoids;

    Sammanfattning : Mitochondria are dynamic organelles that function in a complex interconnected network within the cell. Neurons are sensitive and highly energy demanding cells in the brain which require a functioning mitochondrial network that is able to provide ATP and modulate calcium. LÄS MER

  5. 4. The Potential Use of Degradable Starch Microspheres as a Carrier for Nasal Drug Administration

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

    Författare :Rojda Unal; [2023]
    Nyckelord :Pharmaceutical technology; Nasal administration; Läkemedel; Pulverformiga bärare; Sfärer; Pulverinhalation; Bärarmaterial; Läkemedelseffektivitet; Pulverteknik; Partikelformulering; Nasal deposition; Biology and Life Sciences;

    Sammanfattning : Intranasal drug delivery is a practical and accessible method for treating localized symptoms as well as achieving systemic drug absorption. The approach takes advantage of the permeability, vascularization, and limited enzymatic activity of nasal tissue, leading to enhanced drug absorption. LÄS MER

  7. 5. Design, synthesis, and evaluation of 1-phenylethanol and C2 threitol derivatives as non-pyranose galactose-mimicking inhibitors of Galectin-3

    Master-uppsats, Lunds universitet/Centrum för analys och syntes

    Författare :Qrystal Cruz Giron; [2023]
    Nyckelord :Galectin-3; Galectin-3 inhibitor; 1-phenylethanol; C2 threitol derivative; galactose-mimicking inhibitor; organic chemistry; Chemistry;

    Sammanfattning : Galectins are cytosolic protein family involved in several biological functions such as cell differentiation, cell migration and apoptosis amongst many others. Their presence is also substantial in diseases including acute inflammation, fibrosis, allergies, and cancer. LÄS MER