Sökning: "neoantigen"

Hittade 3 uppsatser innehållade ordet neoantigen.

1. 1. Identification of Immunological Targets for Brain Cancer Immunotherapy

   Master-uppsats, Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

   Författare :Zhenda Wang; [2022]
   Nyckelord :Cancer immunotherapy; brain cancer; neoantigen; MHC HLA; TCR;

   Sammanfattning : Background Cancer immunotherapy has yielded many successes. Yet to some hard-to-treat brain tumors, such as glioblastoma multiforme (GBM) and diffuse intrinsic pontine glioma (DIPG), it still lacks substantial improvement. Neoantigens resulting from mutations in malignant cells are the key targets for employing adoptive cell therapies. LÄS MER

3. 2. A study on the manufacturing of individual-specific antigen peptides and key challenges from a GMP perspective

   Master-uppsats, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

   Författare :Linnea Johansson; [2020]
   Nyckelord :cancer vaccine; peptides; neoantigen; regulatory guidelines; personalised medicine;

   Sammanfattning : Cancer is a global health issue and is estimated to be the second leading cause of death worldwide. Within cancer treatment, it has become attractive to introduce precision medicine to harness the body’s own immune system to fight cancer. LÄS MER

4. 3. Investigating possible approval paths of individualized neoantigen based therapeutic vaccines from a regulatory perspective

   Master-uppsats, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

   Författare :Layla Eng; [2020]
   Nyckelord :Neoantigen vaccine; precision medicine; individualized vaccine; regulatory guidelines;

   Sammanfattning : Introduction: Mortality in cancer has declined during recent years due to more efficient cancer treatments. Some of the novel immunotherapies against cancer under development has a risk of lacking regulatory guidance for the approval, such as neoantigen-based therapeutic vaccines. LÄS MER