Sökning: "single-cell RNA sequencing"

Visar resultat 1 - 5 av 23 uppsatser innehållade orden single-cell RNA sequencing.

  1. 1. Regulatory Driven Clustering of Single-Cell Data; Clustering of single-cell RNA sequencing from glioblastoma with a novel mathematical method

    Master-uppsats, Göteborgs universitet/Institutionen för matematiska vetenskaper

    Författare :Kári Kristjánsson; [2023-08-08]
    Nyckelord :;

    Sammanfattning : Cancer is a leading cause of death worldwide. Single-cell RNA sequencing has arisen as an important method to explore the gene expression of biological cells, including cancer cells. In this study, we deployed a computational algorithm known as ScRegClust to dissect single-cell RNA-sequencing (scRNA-seq) data from brain tumors. LÄS MER

  3. 2. PAMPaR: Parallel Analysis of miRNAs, Proteins and RNAs. Dynamic Profiles of miRNAs, mRNAs and Specific Proteins in Mouse Embryonic Stem Cells Differentiating into Neural Precursors

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Amelie Carlström; [2023]
    Nyckelord :PAMPaR; SPARC; Proximity extension assay; Neuronal differentiation; Mouse embryonic stem cells; PAMPaR; SPARC; Proximity extension assay; Neuronal differentiering; embryonala musstamceller;

    Sammanfattning : MikroRNA-molekyler (miRNA) är viktiga icke-kodande RNA-molekyler för post-transkriptionell reglering av proteinkodande gener. De har även effekter på många cellulära processer såsom differentiering. De biosyntetiska reaktioner som skapar miRNA involverar proteiner som själva regleras av miRNA. LÄS MER

  4. 3. Computational prediction of cell-cell interactions in the brain-tumour microenvironment

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Paula Camargo Romera; [2023]
    Nyckelord :Cancer; Glioblastoma; Computational Biology; Bioinformatics; Microenvironment; Brain tumour; Interactions; Systems Biology;

    Sammanfattning : Glioblastoma is the fastest-growing, and the most common malignant brain tumour in adults. It is normally treated with surgery and radio- or chemotherapy, but the approximate life expectancy is of 15 months with a high probability of cancer recurring. Therefore, there is a need for decreasing its severity. LÄS MER

  5. 4. Developing Automated Cell Segmentation Models Intended for MERFISH Analysis of the Cardiac Tissue by Deploying Supervised Machine Learning Algorithms

    Master-uppsats, KTH/Kemi

    Författare :Julia Rune; [2023]
    Nyckelord :Cell Segmentation; Cellpose; Supervised Machine Learning; MERFISH; Heart Failure; Cellsegmentering; Cellpose; Övervakad Maskininlärning; MERFISH; Hjärtsvikt;

    Sammanfattning : Följande studie behandlar utvecklandet av automatiserade cellsegmenteringsmodeller med avsikt att identifiera gränser mellan celler i hjärtvävnad. Syftet är att möjliggöra analys av data genererad från multiplexed error-robust in situ hybridization (MERFISH). LÄS MER

  7. 5. Molecular characterization of vascular malformations using single-cell RNA sequencing and immunohistological analysis

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Amanda Norrén; [2023]
    Nyckelord :;

    Sammanfattning : CCM is a human disease in which vascular malformations develop in the central nervous system, predominantly in the brain. The malformations which can measure up to several centimeters in size are dilated and leaky vessels, with unstable cellular junctions and thin vessel walls. LÄS MER