Sökning: "Simon Gripvall"

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  1. 1. Structural and Functional Characterisation of the Human Mitochondrial Pyruvate Carrier

    Master-uppsats, Lunds universitet/Kemiska institutionen

    Författare :Simon Gripvall; [2023]
    Nyckelord :biochemistry; complex; MPC; proteoliposomes; pyruvate; transport; Chemistry;

    Sammanfattning : The metabolism of pyruvate in the cell is abnormally regulated in several human diseases, such as type-II diabetes, cancer and neurodegenerative disorders, in which the human mitochondrial pyruvate carrier (HuMPC) sits at a pivotal point. It transports pyruvate across the inner mitochondrial membrane and consists of two proteins, MPC1 and MPC2, and is a potential drug target against these diseases. LÄS MER