Sökning: "insulin-regulated aminopeptidase"

Hittade 3 uppsatser innehållade orden insulin-regulated aminopeptidase.

  1. 1. Conformational Changes in Insulin Regulated Aminopeptidase

    Master-uppsats, Uppsala universitet/Läkemedelsdesign och läkemedelsutveckling

    Författare :Sebastian Moes; [2021]
    Nyckelord :;

    Sammanfattning : Global disease burden due to age related cognitive decline and dementias, especially Alzheimer’s disease, are a growing public health problem. Current treatments fail to completely prevent or cure dementia. LÄS MER

  3. 2. The effects of IRAP-inhibitors in the brain

    Magister-uppsats, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Författare :Dennis Josefsson; [2021]
    Nyckelord :IRAP; insulin-regulated aminopeptidase; IRAP-inhibitors; memory disorders; neurogenerative diseases; cognitive impairments;

    Sammanfattning : The increased understanding of underlying neurobiological processes and their connections to cognitive performance has opened new doors for novel therapeutic strategies that aim to prevent, and even reverse the effects of memory disorders, neurodegenerative diseases and other cognitive impairments. One of the new and exciting drug targets that has emerged as a result of this research is insulin-regulated aminopeptidase (IRAP). LÄS MER

  4. 3. Synthesis of Insulin-Regulated Aminopeptidase (IRAP) inhibitors

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Analytisk kemi; Uppsala universitet/Avdelningen för organisk farmaceutisk kemi

    Författare :Faith Agalo; [2015]
    Nyckelord :Non-peptide IRAP inhibitors; microwave synthesis; cognitive imparement; cognitive enhancers; Alzheimer s disease; spirooxindole dihydroquinazolinone; Angiotensin IV;

    Sammanfattning : The need for alternative cognitive enhancers has risen due to the fact that clinical trial results of the drugs currently approved for treating these disorders have not been satisfactory. IRAP has become a possible drug target for treating cognitive impairment brought about by Alzheimer’s disease, head trauma or cerebral ischemia, among others. LÄS MER