Sökning: "matrix excipient"

Hittade 3 uppsatser innehållade orden matrix excipient.

  1. 1. Matrisbildande hjälpämnen för framställning av spraytorkade partiklar för inhalation

    Kandidat-uppsats, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Författare :Zara Nazari; [2024]
    Nyckelord :Spray drying; dry powder inhalation; matrix excipient; lactose; trehalose; mannitol;

    Sammanfattning : .... LÄS MER

  3. 2. Fused deposition modeling of API-loaded mesoporous magnesium carbonate

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Nanoteknologi och funktionella material

    Författare :Andreas Abdelki; [2020]
    Nyckelord :Additive manufacturing; 3D-printing; Fused deposition modeling FDM ; Fused filament fabrication FFF ; Drug delivery; Amorphous drugs; Mesoporous magnesium carbonate; Upsalite; Cinnarizine; Hydroxypropyl cellulose HPC ; Hydroxypropyl methylcellulose acetate succinate HPMCAS ; Klucel ELF; AquaSolve LG;

    Sammanfattning : In this thesis, the incorporation of drug loaded mesoporous magnesium carbonate as an excipient for the additive manufacturing of oral tablets by fused deposition modeling was investigated. Cinnarizine, a BCS class II drug, was loaded into the pores of the mesoporous material via a soaking method, corresponding to a drug loading of 8.68 wt%. LÄS MER

  4. 3. Suitability of Spray Dried Powder containing Lipids for Inhalation Formulation based on Fine Particle Fraction and Particle Size Distribution

    Uppsats för yrkesexamina på avancerad nivå, Lunds universitet/Livsmedelsteknik och nutrition (master)

    Författare :Hung Nguyen; [2016]
    Nyckelord :Fine Particle Fraction: Particle Size Distribution; Drying; Inhalation; DPI; Dry Powder Inhaler; Powder; Inhaler; Spray drying; Lipids; Inhalation Formulation; Lysozyme; Pharmaceutical Technology; läkemedelsteknologi; Technology and Engineering;

    Sammanfattning : The aim of this master thesis is to provide an indication of the suitability, or otherwise usage, of spray-drying for production of powder aimed for inhalation formulation and comparing the characteristics of the product, with and without lipids. Lipids have a proven effect of delaying release of active drug substances in the cardiovascular system and pulmonary systemic delivery has a number of advantages, chiefly among them being bypassing the first pass metabolism. LÄS MER