Effekten av transplantation av autologa mesenkymala stamceller (MSC) vid sjukdomen multipel skleros

Sammanfattning: Multiple sclerosis (MS) is an autoimmune disease that affects the central nervous system (CNS) and leads to demyelination and loss of CNS neurons. MS usually occurs in young people, and it is mostly women between the ages of 20 and 40 who are affected by the disease. The disease can lead to impairments in motor functions such as walking ability, coordination, reduced balance, and strength. Until now, there is no treatment that can cure the disease, but there is complementary medicine that can suppress the symptoms of the disease or prevent the development of the disease. Nowadays there are studies that show that there may be alternative treatments that can be an ultimate treatment for MS disease that can be effective and beneficial. A novel treatment that researchers have developed is transplantation of autologous mesenchymal multipotent stem cells (MSC), which appear to be the most promising of the emerging treatments of MS. There is research in the field that shows that the treatment is progressive and beneficial. However, there are some study results that show that the treatment can cause side effects. The four chosen articles are reviewed on how effective and safe the treatment with MSC transplantation is in patients with MS. The studies show promising results bur have some shortcomings such as low study population, uneven gender distribution and ethnic considerations. To confirm these results, larger studies with high quality and quantity are needed. The results showed that the treatment gave indications of beneficial effects, including improvements in neurological functions. The Expanded Disability Status Scale (EDSS) value improved during the MSC transplantation in the patients with severe disease which indicate a beneficial effect of this novel treatment.