In-vitro study of antibiotic and strontium release from hydroxyapatite spheres and its PMMA composite

Sammanfattning: The aim of this project was to study the in vitro release of cephalothin, vancomycin and strontium from hydroxyapatite particles and its PMMA composite. The hydroxyapatite spheres containing strontium were prepared in the laboratory. The in vitro release study for the hydroxyapatite was carried out in phosphate buffer saline solution (PBS) with differing pH value at 37 °C for five days and the PMMA composites for 21 days. All of the releases showed a burst release within the first 24 hours followed by a slow release. The pH value of the release medium had influence on the release rate to some extent for the antibiotic release and the acidic solution had a more significant impact on the strontium release. All of the composite groups had a much lower strontium release rate than the strontium release from the hydroxyapatite spheres.