Sökning: "G protein-coupled receptors GPCRs"

Visar resultat 1 - 5 av 11 uppsatser innehållade orden G protein-coupled receptors GPCRs.

1. 1. Orphan G-Protein Coupled Receptors : Can we deorphanize the remaining orphans despite all the challenges?

   Kandidat-uppsats, Linköpings universitet/Institutionen för fysik, kemi och biologi

   Författare :Micaela Andersson; [2022]
   Nyckelord :Deorphanization; Heterodimerization; High-throughput screening; Orphan G-protein Coupled receptor; Pseudogenes; Reversed pharmacology;

   Sammanfattning : G-protein coupled receptors (GPCRs) play a key role in a broad range of biological processes by binding to a wide variety of signaling molecules, which have resulted in 34% of all FDA-approved drugs which target GPCRs. The human genome encodes for approximately 800 GPCR members of which about 140 non-olfactory receptors remain orphans with an unknown function and endogenous ligand. LÄS MER

3. 2. The differential signalling of the succinate receptor SUCNR1/GPR91, through Gi versus Gq

   Master-uppsats, Lunds universitet/Teknisk mikrobiologi

   Författare :Sofie Liljewall; [2022]
   Nyckelord :GPR91; SUCNR1; G protein recruitment; Gi; Gq; TRUPATH biosensor; BRET2; Applied Microbiology; Biology and Life Sciences;

   Sammanfattning : G protein-coupled receptors are the biggest family of membrane bound receptor in the human genome, they are also target for many drugs due to their accessible location in the cell membrane. We have characterized the G protein recruitment of the succinate receptor 1 (SUCNR1/GPR91). LÄS MER

4. 3. Challenging specificity of chemicalcompounds targeting GPCRs with cellprofiling

   Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

   Författare :Anton Davidsson; [2020]
   Nyckelord :cell profiling; gpcr; g-protein coupled receptor;

   Sammanfattning : Screening compounds with image-based analysis is an important part in the processof drug discovery. It is an efficient way to screen compounds as it gives moreinformation than for example HTS. LÄS MER

5. 4. Computational Methods for the structural and dynamical understanding of GPCR-RAMP interactions

   Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

   Författare :Silvia Bahena; [2020]
   Nyckelord :Protein-protein interaction; coarse-grained; G protein-coupled receptors; receptor activity–modifying proteins;

   Sammanfattning : Protein-protein interaction dominates all major biology processes in living cells. Recent studies suggestthat the surface expression and activity of G protein-coupled receptors (GPCRs), which are the largestfamily of receptors in human cells, can be modulated by receptor activity–modifying proteins (RAMPs). LÄS MER

7. 5. Maskininlärningsmetoder för klassificering av G-proteinkopplade receptorer

   Kandidat-uppsats, KTH/Skolan för teknikvetenskap (SCI)

   Författare :Marcus Hägglund; [2019]
   Nyckelord :;

   Sammanfattning : G-proteinkopplade receptorer utgör ett av de största ämnesområderna inom läkemedelsindustrin då approximativt en tredjedel av dagens mediciner binder till dessa. Målet med detta projekt är att använda olika maskininlärningsalgoritmer för att se hur väl de kan klassifiera dessa receptorer i olika tillstånd. LÄS MER