Sökning: "LC-MS MS"

Visar resultat 21 - 25 av 75 uppsatser innehållade orden LC-MS MS.

  1. 21. In silico and in vitro determination of substrate specificity for Breast Cancer Resistance Protein (BCRP) transporter at the blood-brain barrier

    Master-uppsats, Uppsala universitet/Institutionen för farmaci

    Författare :Fen Wang; [2021]
    Nyckelord :BCRP; substrate specificity; BBB; ATP-binding cassette ABC transporter; Drug transport;

    Sammanfattning : Background The Breast Cancer Resistance Protein (BCRP) drug transporter is important for drug disposition and plays a critical role in regulating drug entry into the brain. Its substrate spectrum overlaps with substrates of Multi Drug Resistance Protein 1 (MDR1, P-gp), which influences and complicates the interpretation of data on drug distribution into tissues (e. LÄS MER

  3. 22. The Infection and Uncoating Mechanism of the Giant Melbournevirus

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Sahar Shammakhi; [2020]
    Nyckelord :Giant viruses; Infection mechanism; amoeba; LC-MS MS;

    Sammanfattning : Since their 'discovery' at the turn of the 21st century, giant viruses of the amoeba have captured the fascination of virologists. They have raised a plethora of questions regarding their evolution and ecological significance and have greatly defied a century's old definition of viruses. LÄS MER

  4. 23. Spårmängdsanalys av explosivämnen

    Kandidat-uppsats, Linköpings universitet/Institutionen för fysik, kemi och biologi

    Författare :Cheryl Loorents; [2020]
    Nyckelord :Spårmängdsanalys; explosivämnen; R-salt; TNT; PETN; LC-UV; SPE; LC-MS;

    Sammanfattning : There is an alarming increase of explosions with devastating consequences, the ultimate being loss of life. Furthermore, these kinds of substances have a toxic effect on animals, nature and humans if they are incorrectly disposed. LÄS MER

  5. 24. Investigating the methane producing pathway in lab-scale biogas reactors subjected to sequential increase of ammonium and daily acetate-pulsing

    Master-uppsats, Linköpings universitet/Institutionen för fysik, kemi och biologi

    Författare :Sofia Moberg; [2020]
    Nyckelord :Syntrophic acetate oxidation; syntrophic acetate oxidizing bacteria; Wood-Ljungdahl pathway;

    Sammanfattning : Syntrophic acetate oxidizing bacteria convert acetate into hydrogen and carbon dioxide and through the mutualistic syntrophic partnership with methanogens the products are further converted to methane in biogas processes operating at high ammonia concentrations. There is very little known about SAOBs, only five have been characterized and had their genome analyzed. LÄS MER

  7. 25. Detektion av hydrolyserad β-laktamantibiotika i plasma med Matrix-Assisted Laser Desorption Ionization – Time of Flight Mass Spectrometry och Liquid Chromatography tandem Mass Spectrometry

    Kandidat-uppsats, Örebro universitet/Institutionen för hälsovetenskaper

    Författare :Niklas Thenstedt; [2020]
    Nyckelord :LC-MS MS; MALDI-TOF MS; Enterobacteriaceae; sepsis; piperacillin-tazobactam; cefotaxime; Extended spectrum β-lactamase; hydrolysis; LC-MS MS; MALDI-TOF MS; Enterobacteriaceae; sepsis; piperacillin-tazobaktam; cefotaxim; Extended spektrum β-laktamas; hydrolys;

    Sammanfattning : Introduktion Antibiotikaresistens är ett globalt växande problem. Till gruppen β-laktamantibiotika hör piperacillin-tazobaktam och cefotaxim som båda verkar genom att försvaga cellväggen med kovalenta bindningar till peptidoglykanlagret som lyserar cellen. E. coli och K. LÄS MER