Sökning: "MAPK"

Visar resultat 1 - 5 av 17 uppsatser innehållade ordet MAPK.

  1. 1. The effect of GSK-3 inhibitor SB216763 on the expression and secretion of IL-8 in THP-1 ASC GFP macrophages cells

    Kandidat-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Umaimah Hassen; [2022]
    Nyckelord :;

    Sammanfattning : Inflammation is a part of the innate immune system. It protects the body against foreign invaders such as bacteria and viruses. Inflammation helps to restore the body by removing harmful stimuli and starting the healing process. LÄS MER

  3. 2. The Effects of ACK1 and Cell Density on ErbB3

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Julia Svensson; [2021]
    Nyckelord :;

    Sammanfattning : The ErbB family of receptors are involved in signalling relating to cell proliferation and differentiation through activation of pathways such as PI3K and MAPK. Their overexpression is often found in different cancer types and therefore, their expression is under tight regulation. LÄS MER

  4. 3. Validation of a 3D culture model for toxicity studies in malignant and non-cancerous cells

    Master-uppsats, Lunds universitet/Institutionen för immunteknologi

    Författare :Kajsa Andreasson Dahlgren; [2021]
    Nyckelord :Dose-response; potency; in vitro; 2D model; 3D model; cancer; MEK inhibitor; trametinib; A549; LL47; Western blot; Biology and Life Sciences;

    Sammanfattning : Cancer is a widespread and commonly fatal disease in constant need of new treatments. Traditionally, new pharmaceuticals have been tested in 2D models. This is not ideal, as 2D environments do not reflect the in vivo milieu of the cells. LÄS MER

  5. 4. The effects of NOX2 and NOX4 inhibitors on panc-1 cell viability

    Kandidat-uppsats, Högskolan i Skövde/Institutionen för hälsovetenskaper

    Författare :Karl-Hermann Sielinou Kamgang; [2020]
    Nyckelord :;

    Sammanfattning : Pancreatic cancer is a leading cause of cancer related deaths worldwide and has a low survival rate 1 year after diagnosis. It is therfore important to identify new biomarkers and treatments to improve disease outcome. This experiment investigated the effects of different NOX2 and NOX4 inhibitors on Panc-1 cell lines. LÄS MER

  7. 5. EXPRESSION OF THE THREE PROTO-ONCOGENES, EGFR, MEK AND B-RAF AFTER TRANSFECTION INTO HUMAN CELLS AND THEIR DETECTION BY MASS SPECTROMETRY

    Master-uppsats, Malmö högskola/Fakulteten för hälsa och samhälle (HS)

    Författare :Jimmy Olum; [2016]
    Nyckelord :EGFR; MEK1; BRAF; Mass spectrometry; Gateway Technology; pLenti 6.3 V5.;

    Sammanfattning : When activated by growth factors and mitogens, cellular receptors like EGFR become activated and transmit signals from the cell surface through the MAPK pathway into the nucleus of the cell, in order to elicit a cellular response like growth, apoptosis, proliferation, and survival. Over activation of EGFR even without receptor binding and members of the MAPK pathways like BRAF and MEK1 have been reported in tumorigenesis. LÄS MER