Sökning: "PAR1"

Hittade 3 uppsatser innehållade ordet PAR1.

  1. 1. Human platelet aggregation induced via protease-activated receptor 1 (PAR1)signaling is reversed by nitric oxide (NO) through inhibition of a Rho-kinase/ROCK-mediated pathway

    Master-uppsats, Institutionen för fysik, kemi och biologi

    Författare :Patrik Björn; [2010]
    Nyckelord :Platelet; nitric oxide; PAR1; Rho-kinase; ROCK;

    Sammanfattning : Human platelets are constantly regulated by activating and inhibitory effectors. Thrombin,the most potent platelet agonist, induces signaling through the protease-activated receptors(PARs) 1 and 4 which in turn convey their signal by coupling to G-proteins. LÄS MER

  3. 2. The role of PAR1 and PAR4 in platelet PAI-1 secretion

    Master-uppsats, Institutionen för fysik, kemi och biologi

    Författare :Emma Löfgren; [2009]
    Nyckelord :;

    Sammanfattning : In Sweden about 26000 people are affected by myocardial infarction (MI) every year. Coronary vascular diseases and cerebrovascular diseases with blood flow disruption caused by thrombi are actually the most common cause of death. LÄS MER

  4. 3. Thrombin receptor signalling in platelets: PAR1, but not PAR4, is rapidly desensitized

    Master-uppsats, Institutionen för fysik, kemi och biologi

    Författare :Linda Haglund; [2009]
    Nyckelord :Nitric oxide; PAR1; PAR4; platelets; receptor desensitization;

    Sammanfattning : Platelets play a key role in primary haemostasis but are also related to the pathogenesis of arterial thrombosis. Thrombin is the most effective agonist inducing platelet activation. Human platelets express two G-protein coupled thrombin receptors (GPCRs), called protease activated receptor (PAR)1 and PAR4. LÄS MER