Sökning: "circular dichroism"

Visar resultat 1 - 5 av 21 uppsatser innehållade orden circular dichroism.

  1. 1. Development of a PNA-drug conjugate for pretargeted delivery of cytotoxic drugs

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Theranostics

    Författare :Astrid Haraldsson; [2023]
    Nyckelord :PNA; pretargeting; cancer therapy; cytotoxic payload;

    Sammanfattning : One of the major challenges in cancer treatment is delivering high enough doses of active substance specifically to cancer cells without accumulation in healthy organs. Pretargeting has emerged as a potential solution, where the delivery of a cancer recognizing (primary) agent and a cancer killing (secondary) agent are separated. LÄS MER

  3. 2. Characterisation of structure and stability differences between the C-lobes of human and P. falciparum calmodulin in the presence of calmidazolium

    Kandidat-uppsats, Linköpings universitet/Institutionen för fysik, kemi och biologi

    Författare :Igor Blagojevic; Klara Enockson; Marcus Miras Landelius; Ylva Strid Holmertz; Emelie Weinesson; Emma Örnelöw; [2022]
    Nyckelord :Calmodulin; Calmidazolium; Plasmodium falciparum; Malaria; Fluorescence spectroscopy; UV spectroscopy; CD; Circular dichroism; bioinformatics;

    Sammanfattning : Malaria is a serious disease that can lead to fatal consequences if not treated. It is mainly spread via Plasmodium falciparum, a parasite carried by mosquitoes as host organisms. As a potential way of treating malaria, research is being done on possible inhibitors of calmodulin (CaM) in the parasite. LÄS MER

  4. 3. Investigation of the function of the SH3-like domain of the Saccharopolyspora erythraea iron-dependent regulator

    Master-uppsats, Uppsala universitet/Institutionen för kemi - BMC

    Författare :Carita Hammar; [2022]
    Nyckelord :;

    Sammanfattning : The bacterium Saccharopolyspora erythraea is utilized to produce the widely used antibiotic erythromycin. With the increasing problem of antibiotic resistance, the development of derivatives of the drug is of great importance. To produce antibiotics biosynthetically, it is crucial to understand the metabolic pathways utilized by the bacterium. LÄS MER

  5. 4. Production and Evaluation of a Bombesin Analogue Conjugated to the Albumin-Binding Domain and DOTA for Prostate Cancer Radiotherapy

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Fredrika Landmark; [2021]
    Nyckelord :bombesin; prostate cancer; radiotherapy; human serum albumin; half-life extension; bombesin; prostatacancer; radioterapi; humant serumalbumin; halveringstidsförlängning;

    Sammanfattning : Prostate cancer is one of the most common types of cancer worldwide and claims hundreds of thousands of lives annually. Currently the most common treatment for prostate cancer is external beam radiotherapy, however, this treatment comes with serious side effects since it lacks selectivity for the cancer cells. LÄS MER

  7. 5. Investigation of possible improvements of the stability of bispecific ADAPT proteins

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Ella Eriksson; [2021]
    Nyckelord :Protein purification; Affinity chromatography; ABD-derived domain; ADAPT protein; simultan binding;

    Sammanfattning : The aim of the project was to identify positions and amino acids that contribute to improved structure and stability of bispecific ADAPT proteins. During the 20 weeks project period, different amino acid substitutions were analysed to evaluate the effect on the three-helical structure and stability of bispecific ADAPTs targeting human serum albumin (HSA) and tumor necrosis factor α (TNFα). LÄS MER