Sökning: "microRNA"

Visar resultat 1 - 5 av 31 uppsatser innehållade ordet microRNA.

  1. 1. Investigations of miR-34a structure and dynamics by SHAPE MaP and optimal time between transfection and modification by qPCR

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Ellinor Lindén; [2023]
    Nyckelord :SHAPE MaP; qPCR; miRNA; HNF4α; mRNA-34a; SHAPE MaP; qPCR; miRNA; HNF4α; mRNA-34a;

    Sammanfattning : microRNA (miRNA) är korta icke-kodande RNA sekvenser som har fått ökande uppmärksamhet då de kan binda till mRNA och styra vårt genuttryck. Omkring trettio procent av våra proteinkodande gener styrs av miRNA. miRNA binder till mRNA vilket hindrar dess translation eller leder till nedbrytning av mRNA. LÄS MER

  3. 2. Non-coding RNAs as therapeutic agents : The future of therapy

    Kandidat-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Hederoth Gustaf; Lyngå Olivia; Rudqvist Olivia; Jeppsson Rebecka; Hogolof Saida; Svanberg Sara; Kauppinen Veera; [2022]
    Nyckelord :Non-coding RNA; Oligonucleotide therapeutics;

    Sammanfattning : Non-coding RNA (ncRNA) therapeutics are based on short oligonucleotides, both naturally occurring and artificial, which target RNA in a site-specific way to modulate gene expression. As of today, 12 synthetically produced ncRNA-based drugs are available on the market in the US and Europe, and there is a possibility of more to be approved in the near future. LÄS MER

  4. 3. Comprehensive Analysis of lncRNA and circRNA Mediated ceRNA network in Psoriasis

    Magister-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Saima Imran; [2022]
    Nyckelord :;

    Sammanfattning : Evidence is accumulating that noncoding RNAs and circRNA are involved in psoriasis; however, the competing endogenous RNA (ceRNA) mediated regulatory mechanisms in psoriasis are rarely reported. The research study aimed to comprehensively investigate the differences in the expression levels of circular RNA (circRNA), long non-coding RNA (lncRNA), microRNA (miRNA/miR), and mRNA in psoriasis. LÄS MER

  5. 4. Future diagnostic of Sepsis : Biomarker miRSeps-5 manual vs robotic extraction and optimization of miRNA detection by Two-Tailed RT-qPCR technology

    Kandidat-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Erika Kasaras; [2022]
    Nyckelord :;

    Sammanfattning : Sepsis is a syndrome developed in response to infection when a body’s immune system cannot adequately respond to infection. To this day, sepsis holds a peak position in mortality rates worldwide. Currently, SOFA score and blood culturing as means to diagnose sepsis are standard. LÄS MER

  7. 5. Identification and network analysis of candidate microRNA biomarkers in neuroblastoma : A meta-analysis

    Master-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Andreas Svensson; [2022]
    Nyckelord :;

    Sammanfattning : Neuroblastoma constitutes roughly 8% of all childhood cancers where 95% of all neuroblastoma cases occur before the age of 10. The survival rate of infants and young children is very poor, which alone contributes to research novel biomarkers for classification methods, improved diagnosis and better anti-tumor therapies. LÄS MER