Sökning: "tonicity adjusting agents"

Hittade 1 uppsats innehållade orden tonicity adjusting agents.

  1. 1. Study of surfactant-preservative and protein-preservative interactions in multi-dose injectable formulation

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

    Författare :Javier Lagares Martín; [2023]
    Nyckelord :Phenol; polysorbate 80; cloud point; somatropin; aggregation; titration; light scattering; salt; surfactant; preservative; protein; tonicity adjusting agents; multi-dose injectable formulation; pharmaceutical technology; Technology and Engineering;

    Sammanfattning : Multidose injectable formulations require a preservative such as phenol to ensure sterility and protection against microbial contamination during clinical use. However, it is known that the interaction between these components and non-ionic surfactants such as polysorbate 80, also found in this type of formulations, present incompatibilities, which can lead to decreases in the efficacy of the product. LÄS MER