A simplied Medium SpinyNeuron-model with retained intrinsic characteristics and plateau properties

Sammanfattning: This master thesis studies how a morphological reduction aects theperformance of a biophysically detailed model of a medium spiny neuron. Themorphological reduction is done using a MATLAB toolbox developed forautomatic 3-dimensional morphological reduction. Two versions of the toolboxare developed in which dierent criteria are used during the merge. Theevaluation of the two toolboxes shows that keeping the absolute distance to thesoma of the branching points and the surface area of the dendrites gives a moreaccurate result than if these criteria are not used. These criteria are implementedin Toolbox 2. In total 8 models with dierent maximal compartment length arethen constructed using Toolbox 2. The number of compartments in the resultingmodels range from 1/2 to 1/10 of the compartments in the original model. Furtherthe performance of the reduced models are evaluated against the original model.The results of this evaluation shows that an increasing compartment length givesa decrease in consistency with the response of the original model. However theresponse of all models are largely similar to the original model.