Validation of KIDScore™ D3 Basic, a morphokinetic model for improved embryo selection

Sammanfattning: ABSTRACT Infertility is a medical condition that affects approximately 16 % of Swedish couples in childbearing age and is a condition found in both men and women. When a couple has been trying to conceive for more than 12 months without success they need to see a health care provider. Infertility can be treated with medicine, insemination or assisted reproductive technology such as in-vitro fertilization (IVF) and intra-cytoplasmic sperm injection (ICSI). The aim of this study was to validate a morphokinetic selection model, KIDScore™ D3 Basic, against morphological selection model that is currently in use at the Fertility unit at University hospital in Orebro. A total of 782 embryos with known implantation data were assessed both y use of KIDScore™ D basic and the morphological selection model. The results from the study showed that KIDScore™ D3 Basic better discriminates between implanting and non-implanting embryos. Another strong finding in this study was the notion that presence of multinucleation at the two cell stage decreased chance of implantation significantly. The majority of implanting embryos belonged to the best morphokinetic class, whereas for morphology the majority of implanting embryos belonged to the second best class. The combination it of morphology and morphokinetic is to recommend as clinical use as it provided the best selection tool.