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1. 1. Increased expression of proteins in CHO cells by identification of signal peptides for improved secretion of translated proteins

   Master-uppsats, Linköpings universitet/Teknisk biologi

   Författare :Malin Strannermyr; [2018]
   Nyckelord :Chinese hamster ovary; signal peptide; protein expression; plasmid; library; gene; Fc-fusion; monoclonal antibody; E. coli; flow cytometry; transfection; transformation;

   Sammanfattning : Main purpose of this study was to increase protein expression in Chinese hamster ovary (CHO) cells by improving protein secretion of translated proteins. The goal was to find signal peptides from the screening of signal peptide libraries for improvement of protein secretion using a CHO-cell express selection system. LÄS MER