Sökning: "computational pipeline development"

Visar resultat 1 - 5 av 6 uppsatser innehållade orden computational pipeline development.

1. 1. Computational Pipeline for Analyses of Genome-Wide Nascent Transcription from PRO-seq Data

   Master-uppsats, KTH/Genteknologi

   Författare :Serhat Aktay; [2023]
   Nyckelord :Transcription; functional genomic regions; heat shock response; computational pipeline development; automation.; Genavläsning; genomets funktionella regioner; värmechockrespons; dataanalysutveckling; automatisering;

   Sammanfattning : Celler har en rad olika sätt att försvara sig mot stress för att överleva, främst genom att reglera transkriptionen av gener. En metod för att undersöka hur cellens transkription förändras vid cellulär stress är precision run-on sequencing (PRO-seq). LÄS MER

3. 2. Improving Usability of Bioinformatics Software with an Integrated Web Tool System for Cancer Diagnostics

   Master-uppsats, KTH/Skolan för elektroteknik och datavetenskap (EECS)

   Författare :Solbritt Gateman; [2023]
   Nyckelord :Web development; bioinformatics pipelines; precision medicine; user-centred design; interface design;

   Sammanfattning : Precision cancer medicine is an area of research that involves complex bioinformatics software for the clinical analysis pipelines that sequencing data is passed through. A research team at Karolinska Institutet (KI) is running clinical trials to test new methods of precision cancer medicine and is working on creating a new web application that will be integrated with their two existing applications to aid bioinformaticians in their work of running pipelines and producing clinical reports for the hospitals. LÄS MER

4. 3. Optimering av Pairwise Comparative Modelling för prediktion av antimikrobiella resistensdeterminanter i mikrobiomdata från människa

   Magister-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

   Författare :Gianluca Moretti; [2021]
   Nyckelord :;

   Sammanfattning : The increasing spread of antibiotic resistance among microorganisms is a dangerous threat for human health. It is therefore necessary to have appropriate tools to understand the phenomenon and monitor its development. LÄS MER

5. 4. Protecting Privacy: Automatic Compression and Encryption of Next-Generation Sequencing Alignment Data

   Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Experimentell och klinisk onkologi

   Författare :Wiktor Gustafsson; [2019]
   Nyckelord :data protection; compression; encryption; genomic data; privacy; cancer; ngs; next-generation sequencing; AES; Zstandard; sequencing;

   Sammanfattning : As the field of next-generation sequencing (NGS) matures and the technology grows more advanced, it is becoming an increasingly strong tool for solving various biological problems. Harvesting and analysing the full genomic sequence of an individual and comparing it to a reference genome can unravel information about detrimental mutations, in particular ones that give rise to diseases such as cancer. LÄS MER

7. 5. Identification of personalized multi-omic disease modules in asthma

   Master-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

   Författare :David Martínez Enguita; [2018]
   Nyckelord :modules; asthma; personalized; systems biology; molecular biology; transcriptomics; genomics; networks; disease; biomarker; microarray; individualized; endotype; phenotype;

   Sammanfattning : Asthma is a respiratory syndrome associated with airflow limitation, bronchial hyperresponsiveness and inflammation of the airways in the lungs. Despite the ongoing research efforts, the outstanding heterogeneity displayed by the multiple forms in which this condition presents often hampers the attempts to determine and classify the phenotypic and endotypic biological structures at play, even when considering a limited assembly of asthmatic subjects. LÄS MER