Sökning: "monoclonal antibody"

Visar resultat 16 - 20 av 69 uppsatser innehållade orden monoclonal antibody.

  1. 16. Effektivitet och säkerhet av omalizumab vid behandling av kronisk spontan urtikaria

    Kandidat-uppsats, Linnéuniversitetet/Institutionen för kemi och biomedicin (KOB)

    Författare :Vikki Ta Broddene; [2021]
    Nyckelord :Kronisk spontan urtikaria; kronisk idiopatisk urtikaria; omalizumab; monoklonal antikropp; IgE; utslag; kvaddlar; nässelutslag;

    Sammanfattning : Chronic spontaneous urticaria (CSU) is defined as itchy hives with or without angioedema with a burning sensation that last for six weeks or longer and have no apparent external trigger. The disease occurs in about 1 % of the population. LÄS MER

  3. 17. The effect of deactivation or silencing of tumor stroma with angiogenesis inhibitor on malignancy of tumor metastases

    Master-uppsats, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Författare :Nataly Tachijian; [2021]
    Nyckelord :neuroblastoma; SU11248; angiogenesis; tumor-associated macrophages; immunohistochemistry;

    Sammanfattning : Background: Neuroblastoma (NB) is a pediatric tumor in infants and young children. The survival rate is only around 50 percent for high-risk NB despite advanced and intense multi-modal therapy. Current research aims to find new effective treatment additional to modern therapy to improve prognosis of high-risk NB in children. LÄS MER

  4. 18. Development of a high-throughput platform for generation and early screening of high producing stable cell lines

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Jonathan Karlsson Persson; [2021]
    Nyckelord :CHO-K1; HEK293; CellCelector™; High-throughput screening; Protein A beads; Secondary antibody; CHO-K1; HEK293; CellCelector™; Högkapacitets-screening; Protein A-kulor; Sekundär antikropp;

    Sammanfattning : Produktionen av rekombinanta biofarmaceutiska läkemedel, exempelvis monoklonala antikroppar, är en oumbärlig men ansträngande process. Under 2019 var sju av de tio mest sålda läkemedlen globalt baserade på rekombinant producerade monoklonala antikroppar. LÄS MER

  5. 19. Comparison of Lectins and their suitability in Lectin Affinity Chromatography for isolation of Glycoproteins

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Pontus Andersson; [2020]
    Nyckelord :biotechnology; lectins; chromatography; glycoproteins; lectin affinity chromatography; LAC; ConA; Concanavalin A; bioteknik; lektiner; kromatografi; affinitetskromatografi; glykoproteiner; ConA; Concanavalin A;

    Sammanfattning : Virtually all extracellular proteins in humans are glycoproteins and likewise are many biopharmaceuticals. The glycosylation is directly correlated to biological function and stability of these proteins. The ability to isolate glycoproteins is thus of great importance in many applications. LÄS MER

  7. 20. The art of making a comprehensive stability study

    Master-uppsats, Lunds universitet/Centrum för analys och syntes

    Författare :Roman Lord; [2020]
    Nyckelord :Biopharmaceuticals; mAbs; SEC; stability study design; technical analytical chemistry; teknisk analytisk kemi; Technology and Engineering; Chemistry;

    Sammanfattning : There is a need for harmonisation of stability study designs of monoclonal antibodies. Monoclonal antibodies (mAbs) are widely used in treatments for various diseases. Like all drugs, their quality must be verified through stability studies. LÄS MER