Sökning: "monoclonal antibody"

Visar resultat 21 - 25 av 69 uppsatser innehållade orden monoclonal antibody.

  1. 21. CGRP-hämmare i form av monoklonala antikroppar som profylax mot episodisk och kronisk migrän

    Kandidat-uppsats, Linnéuniversitetet/Institutionen för kemi och biomedicin (KOB)

    Författare :Jenny Gröhn; [2020]
    Nyckelord :CGRP; CGRP-receptor; episodisk migrän; eptinezumab; erenumab; fremanezumab; galcanezumab; kalcitoningenrelaterad peptid; kronisk migrän; monoklonala antikroppar;

    Sammanfattning : Background: Migraine is a common disease with a global prevalence of about 15%. Migraine is divided into two main types; migraine with aura or migraine without aura. Migraine symptoms include moderate or severe unilateral pulsating pain exacerbated by physical activity, nausea and vomiting as well as light and sound sensitivity. LÄS MER

  3. 22. Optimizing signal peptides for expression of recombinant antibodies in HEK293 cells

    Master-uppsats, Linköpings universitet/Institutionen för fysik, kemi och biologi

    Författare :Gustav Myhrinder; [2020]
    Nyckelord :Signal peptide; antibody; mammalian cell; HEK293; secretory pathway;

    Sammanfattning : Monoclonal antibodies are well-established as a therapeutic in the biopharmaceutical market, targeting a variety of diseases and with 79 approved products by the United States Food and Drug Administration in December 2019. Therapeutic monoclonal antibodies are commonly produced as recombinant proteins in mammalian cell lines, due to their capacity of post-translational modifications, most notably glycosylation. LÄS MER

  4. 23. Behandling av HER2-positiv bröstcancer med antikroppen trastuzumab emtansin (T-DM1) : En undersökning av läkemedlets effektivitet och relationen till biomarkörer med avseende på överlevnaden hos HER2-positiva patienter

    Kandidat-uppsats, Linnéuniversitetet/Institutionen för kemi och biomedicin (KOB)

    Författare :Emmeli Ferm; [2020]
    Nyckelord :HER2-positiv bröstcancer; T-DM1; trastuzumab emtansin;

    Sammanfattning : Bröstcancer räknas idag till den vanligaste cancerformen bland kvinnor. År 2018 avled drygt 1400 personer till följd av sjukdomen, nästan alla som avled var diagnostiserade med metastaserad bröstcancer. LÄS MER

  5. 24. Production and validation of anti-HCV antibodies for viral neutralization

    Master-uppsats, KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Författare :Megan Olga García Mark; [2020]
    Nyckelord :Cloning; antibody; infection; HCV; IgG production; molecular biology; cell factory; plasmid design; immunology;

    Sammanfattning : Hepatitis-C Virus (HCV) remains the leading cause of liver transplant in the US and the UK, and the World Health Organization (WHO) estimates that 71 million people are infected worldwide. A vaccine would drastically impact the healthcare-associated burdens that HCV causes globally. LÄS MER

  7. 25. Daratumumab treatment increases the risk of upper respiratory tract infections in multiple myeloma : A systematic review and meta-analysis

    Magister-uppsats, Södertörns högskola/Miljövetenskap

    Författare :Raphaela Mayerhofer; [2020]
    Nyckelord :;

    Sammanfattning : Purpose This systematic review and meta-analysis was conducted to investigate the risk of upper respiratory tract infection in multiple myeloma patients undergoing antineoplastic therapy with the anti-CD38 monoclonal antibody Daratumumab. Methods PubMed, CINAHL, and Scopus databases were searched for publications describing rate of upper respiratory tract infections in multiple myeloma patients treated with Daratumumab. LÄS MER