Sökning: "neuroblastoma"

Visar resultat 1 - 5 av 34 uppsatser innehållade ordet neuroblastoma.

  1. 1. Combining doxorubicin and gemcitabine with targeted drugs as a treatment option for high-risk neuroblastoma

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Alexandra Johannesson; [2023]
    Nyckelord :neuroblastoma; doxorubicin; gemcitabine; targeted drugs; ATM; neuroblastom; doxorubicin; gemcitabin; målinriktade läkemedel; ATM;

    Sammanfattning : Neuroblastom är en barncancer som uppstår ur det sympatiska nervsystemet och drabbar omkring 15 barn i Sverige varje år. Högriskvarianten är associerad med mycket hög dödlighet och risk för återfall, vilket tros ha att göra med att tumörernas ovanligt heterogena sammansättning tillåter resistenta subpopulationer att motstå konventionella behandlingsmetoder. LÄS MER

  3. 2. Stress response in cancer cell lines

    Magister-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Nada Ali; [2023]
    Nyckelord :;

    Sammanfattning : Globally, the cases of cancer have been on the rise. This has led to increasing research to find a lasting solution to carcinogenesis. The increase in cancer cases can be due to a change in people’s lifestyles, such as diet and exercise routines which have changed for the worse. LÄS MER

  4. 3. CYP2D6 loss of heterozygosity - a potential target for neuroblastoma therapy

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Jordan Dupuis; [2023]
    Nyckelord :Loss of Heterozygosity; CYP2D6; Neuroblastoma; Collateral Lethality; Precision Cancer Medicine;

    Sammanfattning : Loss of heterozygosity events, whereby alleles are lost at heterozygous chromosomal loci, are associated with cancer formation and may result in the deletion of numerous genes encoding enzymes that have critical activities within the cell. Consequently, vulnerabilities are created that are absent in normal cells which can be targeted using a precision medicine approach called collateral lethality. LÄS MER

  5. 4. Digital Image Analysis using Qupath to determine immune cell content in formalin-fixed, paraffin-embedded murine neuroblastoma tumors

    Master-uppsats, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Författare :Anton Bergström Holm; [2023]
    Nyckelord :Neuroblastoma; Tumor-associated neutrophils TANs ; Digital image analysis; QuPath;

    Sammanfattning : Neuroblastoma (NB), an extracranical solid tumor, is among the most prevalent cancers affecting children, particularly those under the age of five. High-risk NB presents a survival rate just below 50 %. Angiogenesis, a crucial process in NB, is induced by various pro-angiogenic factors. LÄS MER

  7. 5. System level analysis of Immune system in children with solid tumors

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning; Uppsala universitet/Science for Life Laboratory, SciLifeLab

    Författare :Nadia Hassan Shamas; [2022]
    Nyckelord :Immune system in Children; Cancer; Medicines;

    Sammanfattning : Over the last few years, significant immune system changes have been observed in tumor patients exposed to different treatments. Moreover, evaluation and prediction of the responses of treatments given to these patients can become a key component. LÄS MER