Sökning: "targeted drugs"

Visar resultat 1 - 5 av 34 uppsatser innehållade orden targeted drugs.

  1. 1. DIFFERENCES ON THE IMPACTS AND ORIGINS OF POLLEN IN FOUR MAJOR SWEDISH CITIES BETWEEN 2014 AND 2019

    Master-uppsats, Göteborgs universitet / Institutionen för biologi och miljövetenskap

    Författare :Jean-Patrick Ridet-Lagorce; [2024-02-12]
    Nyckelord :Pollen; Allergy; Antihistaminic; Airborne transport; Geographical origins;

    Sammanfattning : Allergies are widespread in the world and coming from various sources, one of the causes being airborne allergens and especially, pollen. The negative impact of pollen is enhanced by pollution and climate change which are some of the biggest issue humankind is facing today. LÄS MER

  3. 2. Combining doxorubicin and gemcitabine with targeted drugs as a treatment option for high-risk neuroblastoma

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Alexandra Johannesson; [2023]
    Nyckelord :neuroblastoma; doxorubicin; gemcitabine; targeted drugs; ATM; neuroblastom; doxorubicin; gemcitabin; målinriktade läkemedel; ATM;

    Sammanfattning : Neuroblastom är en barncancer som uppstår ur det sympatiska nervsystemet och drabbar omkring 15 barn i Sverige varje år. Högriskvarianten är associerad med mycket hög dödlighet och risk för återfall, vilket tros ha att göra med att tumörernas ovanligt heterogena sammansättning tillåter resistenta subpopulationer att motstå konventionella behandlingsmetoder. LÄS MER

  4. 3. Quantification of DNA Nanoballs Using Image Processing Techniques

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Avdelningen Vi3

    Författare :Sara Lindberg; [2023]
    Nyckelord :image analysis; fluorescence microscopy; quantification; DNA; rolling circle amplification; machine learning; deep learning; transfer learning; neural networks;

    Sammanfattning : In gene editing, it is important to identify the number of edited and unedited nucleic acids in the development of new therapies and drugs. Countagen is developing a technology for accelerating genomic research and their product is called GeneAbacus. LÄS MER

  5. 4. Evaluating targeted combination therapies in EGFR wild-type non-small-cell lung cancer using mass spectrometry-based proteomics

    Master-uppsats, Lunds universitet/Institutionen för immunteknologi

    Författare :Johan Thorsson; [2023]
    Nyckelord :Biology and Life Sciences;

    Sammanfattning : Survival for non-small cell lung cancer (NSCLC) patients has been significantly improved by epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in patients with EGFR mutations. However, certain subpopulations of NSCLC patients with EGFR wild-type (wt) status have been shown to also respond to EGFR-TKIs. LÄS MER

  7. 5. CYP2D6 loss of heterozygosity - a potential target for neuroblastoma therapy

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Jordan Dupuis; [2023]
    Nyckelord :Loss of Heterozygosity; CYP2D6; Neuroblastoma; Collateral Lethality; Precision Cancer Medicine;

    Sammanfattning : Loss of heterozygosity events, whereby alleles are lost at heterozygous chromosomal loci, are associated with cancer formation and may result in the deletion of numerous genes encoding enzymes that have critical activities within the cell. Consequently, vulnerabilities are created that are absent in normal cells which can be targeted using a precision medicine approach called collateral lethality. LÄS MER