Sökning: "protein design"

Visar resultat 1 - 5 av 146 uppsatser innehållade orden protein design.

  1. 1. Drought resistance of Ectomycorrhizal fungi in the Suillus genus

    Master-uppsats, SLU/Dept. of Forest Mycology and Plant Pathology

    Författare :Patricia Salén; [2024]
    Nyckelord :Ectomycorrhiza; drought; Suillus;

    Sammanfattning : Rising instances of drought are causing more tree seedling fatalities post-nursery outplanting. In the face of climate change, fostering resilient forestry practices is imperative for preserving the health and functionality of our forests. LÄS MER

  3. 2. The association between obesity, low-grade inflammation, self-reported knee symptoms and radiographic knee osteoarthritis in individuals with knee pain : A longitudinal cohort study

    Magister-uppsats, Högskolan i Halmstad/Akademin för företagande, innovation och hållbarhet

    Författare :Alma Buer; [2024]
    Nyckelord :osteoarthritis knee pain; artros knä smärta;

    Sammanfattning : Abstract  Background One of the earliest signs of knee osteoarthritis (OA) is knee pain which correlates with inflammation and disease severity. Knee OA affects 260 million worldwide, and is in similarity with obesity, characterized by ongoing low-grade inflammation. LÄS MER

  4. 3. Gene expression editing in myeloma cell lines using CRISPR/Cas9 technique

    Kandidat-uppsats, Uppsala universitet/Institutionen för medicinsk cellbiologi

    Författare :Wilma Wadman; [2023]
    Nyckelord :BMPR1A; BMPR2; bone morphogenetic protein; gene knockout; multiple myeloma;

    Sammanfattning : Multiple myeloma, or myeloma, is a bone marrow cancer which characterizes by uncontrolled proliferation of mutant plasma cells. It is a disease that claims many lives every year, mostly due to the absence of curative treatment. Finding a suitable treatment is therefor of great importance. LÄS MER

  5. 4. Design and Evaluation of Peptide Binders : In silico evaluation and comparison of generative AI for de novo peptide binder design

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Beräkningsbiologi och bioinformatik

    Författare :Linde Brokmar; [2023]
    Nyckelord :Protein design; de novo design; protein engineering; generative ai; machine learning; peptide binders; AF2; EvoBind; RFdiffusion; ProteinMPNN;

    Sammanfattning : Peptide binders are short proteins that bind to larger proteins. Due to peptide binders having high specificity and being cheap to synthesize, they are a prime candidate for drug design. Creating new proteins in silico can be divided into three steps: protein backbone generation, sequence design, and computational filtering. LÄS MER

  7. 5. Characterization of Mitilysin Pores by Cryo-electron Microscopy

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Vladimir Novakovic; [2023]
    Nyckelord :Mitilysin; Mly; Structural Biology; Cryo-EM; pore; toxin; pore forming proteins; pore forming toxins; PFP; PFT;

    Sammanfattning : Pore forming toxins (PFTs) are a large group of proteins found mainly in bacteria with some exceptions found in animals. They bind and form pores in their target membranes and form pores, which leads to cell death. Among these are cholesterol-dependent cytolysins (CDC), which require the presence of cholesterol to bind target membranes. LÄS MER