Sökning: "AF2"

Hittade 5 uppsatser innehållade ordet AF2.

  1. 1. Design and Evaluation of Peptide Binders : In silico evaluation and comparison of generative AI for de novo peptide binder design

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Beräkningsbiologi och bioinformatik

    Författare :Linde Brokmar; [2023]
    Nyckelord :Protein design; de novo design; protein engineering; generative ai; machine learning; peptide binders; AF2; EvoBind; RFdiffusion; ProteinMPNN;

    Sammanfattning : Peptide binders are short proteins that bind to larger proteins. Due to peptide binders having high specificity and being cheap to synthesize, they are a prime candidate for drug design. Creating new proteins in silico can be divided into three steps: protein backbone generation, sequence design, and computational filtering. LÄS MER

  3. 2. Determining Protein Conformational Ensembles by Combining Machine Learning and SAXS

    Master-uppsats, KTH/Tillämpad fysik

    Författare :Samuel Eriksson Lidbrink; [2023]
    Nyckelord :AlphaFold; AlphaFold2; SAXS; protein conformational ensembles; machine learning; protein conformations; reweighting; SAXS; AlphaFold; AlphaFold2; proteinkonformationsensembler; maskininlärning; proteinkonformationer; omviktning;

    Sammanfattning : In structural biology, immense effort has been put into discovering functionally relevant atomic resolution protein structures. Still, most experimental, computational and machine learning-based methods alone struggle to capture all the functionally relevant states of many proteins without very involved and system-specific techniques. LÄS MER

  4. 3. A Comparative Study of Electrodes and Membranes for Anion Exchange Membrane Water Electrolysis Systems

    Master-uppsats, KTH/Tillämpad elektrokemi

    Författare :Parth Omprakash Dayama; [2021]
    Nyckelord :water electrolysis; membrane; electrocatalysts; anion exchange membrane; hydrogen; vattenelektrolys; membran; elektrokatalysatorer; anjonbytande membran; vätgas;

    Sammanfattning : Vätgas kan framställas från förnybara energikällor genom vattenelektrolys med anjonbytande membran (AEMWE). AEMWE har vissa fördelar jämfört med traditionell alkalisk vattenelektrolys och elektrolysmed protonledande membran. LÄS MER

  5. 4. Techno-Economic Analysis of Small-Scale Polygeneration Systems for a Ground Based Air Defence Operations Center in the Swedish Armed Forces

    Master-uppsats, KTH/Kraft- och värmeteknologi

    Författare :Alma Klipic; Sidar Eken; [2020]
    Nyckelord :Polygeneration; STandUP;

    Sammanfattning : Climate change is an important topic of today's discussion where scientists have determined that a large proportion of the increasing global temperatures is a product of the increasing greenhouse gases in the atmosphere. Globally it is expected that the share of renewable power generation is set to increase with 50 % between 2019 and 2024. LÄS MER

  7. 5. Aqueous Phase Geochemical Characterization and Delineation of Low Arsenic Aquifers in Matlab Upazila, SE Bangladesh.

    Master-uppsats, KTH/Miljögeokemi och ekoteknik

    Författare :Rajib Hassan Mozumder; [2011]
    Nyckelord :arsenic; Bangladesh; groundwater; mitigation; color tool; aquifer; highstand; lowstand;

    Sammanfattning : The fact that the former highstand whitish sediments of Plio-Pleistocene and lowstand off-white/red sediments of Late Pleistocene containing low As concentrations in the Bengal basin forms the premise for developing a color tool by the ‘Sustainable Arsenic Mitigation Project’ (SASMIT) to guide the local drillers of Matlab, SE Bangladesh, so that they can target low As aquifers. Groundwater samples collected from the black group of sediments representing a highly reducing environment contains very high concentrations of As, Fe2+ , NH4+, PO43-, HCO3–, and DOC and very low SO42- and Mn2+ concentrations; and vice-versa for the red/offwhite/white group of sediments, thus representing a less reducing condition. LÄS MER