Sökning: "protein conformations"

Visar resultat 1 - 5 av 13 uppsatser innehållade orden protein conformations.

  1. 1. Prediction of multiple conformational states of membrane proteins

    Master-uppsats, Linköpings universitet/Bioinformatik

    Författare :Tobias Thorén; [2024]
    Nyckelord :Bioinformatics; Protein prediction; AlphaFold;

    Sammanfattning : Predicting protein structures has long been an area of active research in the field ofbioinformatics. Great strides have recently been made in this area by googles DeepMindteam. They developed an AI called AlphaFold which is able to make the most accuratepredictions of protein structures as of date. LÄS MER

  3. 2. Transient state UV spectroscopy of Tyrosine and Tyrosine-containing protein

    Master-uppsats, KTH/Tillämpad fysik

    Författare :Hongjian Chen; [2023]
    Nyckelord :Tyrosine; Calmodulin; Autofluorescence; Transient-state monitoring; Electronic state transitions; Tyrosin; Calmodulin; Autofluorescens; Transient-tillståndsövervakning; Elektroniska tillståndsövergångar;

    Sammanfattning : The aromatic amino acids tryptophan, tyrosine, and phenylalanine have been extensively used for different label-free protein studies. These investigations extract information on protein conformations and interactions from the emitted fluorescence's intensity, wavelength, and/or polarization. LÄS MER

  4. 3. Determining Protein Conformational Ensembles by Combining Machine Learning and SAXS

    Master-uppsats, KTH/Tillämpad fysik

    Författare :Samuel Eriksson Lidbrink; [2023]
    Nyckelord :AlphaFold; AlphaFold2; SAXS; protein conformational ensembles; machine learning; protein conformations; reweighting; SAXS; AlphaFold; AlphaFold2; proteinkonformationsensembler; maskininlärning; proteinkonformationer; omviktning;

    Sammanfattning : In structural biology, immense effort has been put into discovering functionally relevant atomic resolution protein structures. Still, most experimental, computational and machine learning-based methods alone struggle to capture all the functionally relevant states of many proteins without very involved and system-specific techniques. LÄS MER

  5. 4. Towards time-resolved cryo-EM of SARS-CoV-2 replication-transcription complex and Staphylococcus aureus DNA gyrase

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Anna Králová; [2023]
    Nyckelord :time-resolved cryo-EM; DNA gyrase; SARS-CoV-2; replication-transcription complex; protein purification;

    Sammanfattning : Time-resolved cryo-EM has already provided ground-breaking discoveries in various fields, including structural biology, biochemistry, and drug development. Compared to traditional structural biology methods where mostly stabilized conformations are reconstructed, the main advantage of time-resolved cryo-EM is its ability to capture dynamic processes in biological samples at near-atomic resolution, which allows for studying biological structures as they change and interact in real-time. LÄS MER

  7. 5. Optimizing the Production of Aurora Kinase A and Validation of Constructs with different Sequential Lengths

    Master-uppsats, Linköpings universitet/Kemi

    Författare :Linnea Pierre; [2022]
    Nyckelord :Protein; Protein chemistry; Aurora Kinase A; Aurora A; Cancer; Structural Biology; Cancer research;

    Sammanfattning : Aurora Kinase A is a kinase involved in multiple signaling pathways and interactions during mitosis, making it an essential kinase that deregulated causes cancer diseases in affected patients. Structural research shows mainly static snapshots of possible conformations of the partly disordered protein. LÄS MER