Sökning: "Fluorometric microculture cytotoxicity assay"

Hittade 4 uppsatser innehållade orden Fluorometric microculture cytotoxicity assay.

  1. 1. Validation of in vitro cytotoxicity assays for cancer chemotherapy combining Celltiter Glo 2.0 assay with FMCA

    Kandidat-uppsats, Uppsala universitet/Institutionen för medicinsk cellbiologi

    Författare :Mohanad Hajyahia; [2022]
    Nyckelord :Cellviability; Celltiter-Glo 2.0 reagent; fluorometric microculture cytotoxic assay; fluorescein diacetate; MTT assay and Survival Index SI % .;

    Sammanfattning : Background: Cancer is a common disease, and the choice of treatment becomes more difficult over time due to chemotherapy resistant in cancer cells. To improve the in vitroassay and the individual cancer treatment, a luminescence-based endpoint assay, CellTiter Glo 2. LÄS MER

  3. 2. The screening for novel proteasome inhibitors as a treatment of cancer using IncuCyte FLR and fluorometric microculture cytotoxicity assay.

    Kandidat-uppsats, Institutionen för medicinsk biokemi och mikrobiologi

    Författare :Olga Golovko; [2011]
    Nyckelord :Anticancer drug development; proteasome inhibition; chemotherapy; image-based screening assay; FMCA.;

    Sammanfattning : The problem of finding targeted medicine is a central problem in chemotherapy. From this point of view the ubiquitin-proteasome system is a highly promising object in the pharmaceutical approach. Proteasome plays a critical role in cellular protein degradation, cell cycle and apoptosis regulation. LÄS MER

  4. 3. Methodological aspects within the FMCA-method : do incubation time and the amount of tumor cells influence the antitumoral effect?

    Kandidat-uppsats, Institutionen för medicinsk biokemi och mikrobiologi

    Författare :Johanna Svensson; [2008]
    Nyckelord :Fluorometric microculture cytotoxicity assay; Cytotoxic effect; Drug decay; Chemotherapy; Tumor cell concentration;

    Sammanfattning : ABSTRACT Chemotherapy is a common method used for cancer treatment. Especially when it concerns cancers that have grown invasively it seems to be the only efficient treatment due to the substances ability to reach and affect almost the entire body. LÄS MER

  5. 4. Do the new signal transduction modulators have activity in vitro in tumor cells from ovarian carcinoma and lymphoma?

    Kandidat-uppsats, Institutionen för medicinsk biokemi och mikrobiologi

    Författare :Desiré Lundin; [2005]
    Nyckelord :Anticancer drug development; ovarian carcinoma; lymphoma; FMCA; cytotoxic drugs; in vitro assay;

    Sammanfattning : During the last decades, chemotherapy with cytotoxic drugs has played a significant role in cancer therapy. It’s important to develop new anticancer drugs, and drug sensitivity testing in vitro can be used to find the right diagnosis for the newly developed substances. LÄS MER