Sökning: "LC-qTOF-MS"

Hittade 4 uppsatser innehållade ordet LC-qTOF-MS.

  1. 1. Impact of PFAS exposure on the fecal metabolome

    Kandidat-uppsats, Örebro universitet/Institutionen för naturvetenskap och teknik

    Författare :Lisa Johansson; [2022]
    Nyckelord :Gut metabolites; LC-qTOF-MS; PFAS;

    Sammanfattning : The human gut microbiota plays a crucial role in human health and therefore imbalances in gut microbiota functioning can lead to the development of metabolic disorders. Short-chain fatty acids (SCFA), tricarboxylic acid (TCA) cycle metabolites, bile acids (BA) and other metabolites are the essential compounds for the metabolome. LÄS MER

  3. 2. Impact of polychlorinated biphenyl- and organochlorine pesticide exposure on faecal metabolome

    Kandidat-uppsats, Örebro universitet/Institutionen för naturvetenskap och teknik

    Författare :Maja Näsman; [2022]
    Nyckelord :Gut microbiota; polychlorinated biphenyls; organochlorine pesticides; tricarboxylic acid cycle; bile acids; LC-qTOF-MS.;

    Sammanfattning : The gut microbiota plays a major part in maintaining the health of a human host. Countless of crucial functions in the body, including immune responses, cell signaling and energy metabolism to name a few, are conducted by the gut microbiota and its metabolites. LÄS MER

  4. 3. Implementation of a straightforward derivatizationmethod for the simultaneous analysis of short chainfatty acids and tricarboxylic acid cycle metabolitesby LC-qToF-MS.

    Kandidat-uppsats, Örebro universitet/Institutionen för naturvetenskap och teknik

    Författare :Renée Levisson; [2021]
    Nyckelord :Short-chain fatty acids; tricarboxylic acid TCA cycle; chemical derivatization; 3-nitrophenylhydrazine;

    Sammanfattning : Short-chain fatty acids (SCFAs) and the tricarboxylic acid (TCA) cycle metabolites aresmall hydrophilic compounds that play crucial roles in biological species ranging fromenergy metabolism, immune homeostasis to cellular signalling. There is a need for reliableand precise quantification of these metabolites in biological matrices as they can providecrucial information of metabolic status and potentially be used as diagnostic biomarkersfor different pathological and physiological conditions. LÄS MER

  5. 4. Characterization of hepatocyte derived metabolites of various New Psychoactive Substances using LC-QTOF-MS.

    Kandidat-uppsats, Linköpings universitet/Institutionen för fysik, kemi och biologi

    Författare :Sarah Ingvarsson; [2020]
    Nyckelord :4-fluoro-CUMYL-5-fluoro-PICA; synthetic cannabinoid; incubation; metabolites.;

    Sammanfattning : New psychoactive substances are becoming increasingly common in many parts of the world, and some of them are marketed as “legal highs” and are produced to circumvent the drug legislation, and they come in many unregulated forms. The aim of this research was to characterize the metabolites of a new psychoactive substance and hence provide the fundamental data needed for further research of toxicity and future drug testing. LÄS MER