Sökning: "Pharmacokinetics"

Visar resultat 11 - 15 av 52 uppsatser innehållade ordet Pharmacokinetics.

  1. 11. Development of artificial neural networks for the prediction of outlying and influential individuals from pharmacokinetic and pharmacodynamic models

    Master-uppsats, Uppsala universitet/Institutionen för farmaci

    Författare :Osama Qutishat; [2022]
    Nyckelord :Machine learning; pharmacometrics; Neural networks; pop-pk;

    Sammanfattning : Nonlinear Mixed effect models are often used to describe population pharmacokinetics (PK) and Pharmacodynamics (PD) and play an important part of drug development both from regulatory and industry point of view. However, they can be time consuming and computationally expensive to develop. LÄS MER

  3. 12. Pharmacokinetic changes of meropenem in sepsis patients: A Comparative Review

    Uppsats för yrkesexamina på grundnivå, Uppsala universitet/Institutionen för farmaci

    Författare :Rami Osman Abubaker; [2022]
    Nyckelord :;

    Sammanfattning : Background: Sepsis is a life-threatening organ dysfunction occurring during infections. Meropenem is a hydrophilic β-lactam carbapenem antibiotic. Its pharmacokinetic parameters are expected to change due to sepsis-induced physiological alterations and will thus require altered dosing strategies for optimal treatment of sepsis patients. LÄS MER

  4. 13. Litteraturöversikt av farmakogenomik hos barnonkologiska patienter relaterat till cytostatikainducerad toxicitet

    Magister-uppsats, Uppsala universitet/Institutionen för farmaci

    Författare :Sarah Jannab; [2022]
    Nyckelord :;

    Sammanfattning : Literature review of pharmacogenomics in pediatric oncology patients related to chemotherapy-induced toxicity Abstract Background: As children are expected to live long after their treatment of cancer, it is important to reduce the risk of toxicities. Chemotherapy-induced toxicities can result in interruption or discontinuation of treatment, and the variability in toxicities among pediatric patients can be explained by inter-individual variability in pharmacodynamics and pharmacokinetics. LÄS MER

  5. 14. Populations PK-modellering för IR-formulering av Gliclazid

    Master-uppsats, Uppsala universitet/Institutionen för farmaci

    Författare :Haneen Hussein; [2022]
    Nyckelord :Typ 2-diabetes; Gliclazid; Populations PK-modellering; Monolix;

    Sammanfattning : Introduction: Type-2 diabetes is one of the most common metabolic diseases characterized by elevated blood sugar levels in the body. The disease is caused by lost insulin sensitivity and insufficient insulin production, which leads to an increase in sugar levels in the blood. LÄS MER

  7. 15. Automatic Development of Pharmacokinetic Structural Models

    Master-uppsats, Uppsala universitet/Institutionen för farmaci

    Författare :Alzahra Hamdan; [2022]
    Nyckelord :pharmacometrics; non-linear mixed effects; modelling; pharmacokinetics; NONMEM; automation; exhaustive algorithm; stepwise algorithm; structural models; inter-individual variability; residual error models; model selection;

    Sammanfattning : Introduction: The current development strategy of population pharmacokinetic models is a complex and iterative process that is manually performed by modellers. Such a strategy is time-demanding, subjective, and dependent on the modellers’ experience. LÄS MER