Sökning: "Pharmacokinetics"

Visar resultat 16 - 20 av 52 uppsatser innehållade ordet Pharmacokinetics.

1. 16. Identifiability of pharmacological models from data

   Uppsats för yrkesexamina på avancerad nivå, Lunds universitet/Institutionen för reglerteknik

   Författare :Amina Gojak; [2021]
   Nyckelord :Technology and Engineering;

   Sammanfattning : In order to automate anaesthesia in patients using propofol, closed-loop control systems with models that describe the time course of the drug effects on the body are required, usually being represented by pharmacokinetics and pharmacodynamics(PKPD). This thesis focused on evaluating parameter identifiability for the PK part of the model, using a model proposed by Eleveld et al. LÄS MER

3. 17. Effects of antibody labeling chemistry on assays developed for the Gyrolab immunoassay platform

   Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Molekylär systembiologi

   Författare :Julia Dencker; [2021]
   Nyckelord :Antibodies; Labeling chemistry; Site-specific labeling; Immunoassay; Gyrolab;

   Sammanfattning : The aim of this project was to make a comparison of the effects of antibody labeling chemistries on assays developed for the Gyrolab immunoassay platform. One of the labeling techniques was a heterogenous labeling technique targeting amino groups on the antibody. LÄS MER

4. 18. Comparison of Multiple Models for Diabetes Using Model Averaging

   Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaci

   Författare :Alex Al-Mashat; [2021]
   Nyckelord :pharmacometrics; population pharmacokinetics; pop-pk; pop-PK diabetes; model averaging; MA; cross-validation; cv; CV; akaike information criterion; Akaike; aic; AIC; MPG; mpg; FPG; fpg; FPI; fpi; HbA1c; hba1c; farmakometri; populationsfarmakokinetik; diabetes; model averaging; MA; cross-validation; cv; CV; akaike; Akaike; aic; AIC; MPG; mpg; FPG; fpg; FPI; fpi; HbA1c; hba1c;

   Sammanfattning : Pharmacometrics is widely used in drug development. Models are developed to describe pharmacological measurements with data gathered from a clinical trial. The information can then be applied to, for instance, safely establish dose-response relationships of a substance. LÄS MER

5. 19. Optimized design recommendation for first pharmacokinetic in vivo experiments for new tuberculosis drugs using pharmacometrics modelling and simulation

   Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaci

   Författare :Albin Leding; [2021]
   Nyckelord :Pharmacokinetics; Pharmacometrics; Pharmacology; population pharmacokinetics; physiologically-based pharmacokinetics; in vitro to in vivo extrapolation; IVIVE; PBPK; PK; popPK; tuberculosis; model informed approach; first in vivo pharmacokinetic experiment; mouse; mice; PKSim; NONMEM; in vitro; in vivo;

   Sammanfattning : Tuberculosis, the leading cause of death by a single infection disease caused by bacteria, requires long treatments and the bacteria are prone to develop drug resistance. Therefore, new efficient treatment regiments needs developing, which requires new tools for drug development. LÄS MER

7. 20. Patienters läkemedelsanvändning vid inskrivning inför elektiv urologisk kirurgi

   Magister-uppsats, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

   Författare :Jonas Nygren; [2020]
   Nyckelord :Läkemedel Urologi Inskrivning Elektiv kirurgi Hälsobeskrivning Apotekare;

   Sammanfattning : Abstract Elective urological patients’ medication usage at the time of admission Author: Nygren. J. Supervisor: Gillespie. U. LÄS MER