Sökning: "Targeted Mutation"

Visar resultat 1 - 5 av 10 uppsatser innehållade orden Targeted Mutation.

  1. 1. Knockout of transcription factor MYB28 by CRISPR/Cas9 for reducing glucosinolate content in rapeseed (Brassica napus L.)

    Master-uppsats, SLU/Dept. of Plant Breeding (from 130101)

    Författare :Anusha Harshani Bogahawatta; [2023]
    Nyckelord :CRISPR Cas9; Glucosinolates; ; MYB28; protoplast; ; rapeseed; ; ribonucleoprotein; ; transcription factor;

    Sammanfattning : Rapeseed cake is a protein-rich by-product from the rapeseed oil extraction process. It contains high levels of glucosinolates (GSLs), which possess anti-nutritional functions after being hydrolyzed. Moreover, the hydrolyzed products of GSLs produce an extremely bitter taste. LÄS MER

  3. 2. Evaluating targeted combination therapies in EGFR wild-type non-small-cell lung cancer using mass spectrometry-based proteomics

    Master-uppsats, Lunds universitet/Institutionen för immunteknologi

    Författare :Johan Thorsson; [2023]
    Nyckelord :Biology and Life Sciences;

    Sammanfattning : Survival for non-small cell lung cancer (NSCLC) patients has been significantly improved by epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in patients with EGFR mutations. However, certain subpopulations of NSCLC patients with EGFR wild-type (wt) status have been shown to also respond to EGFR-TKIs. LÄS MER

  4. 3. Filtering of Clinical NGS Data to Improve Low Allele Frequency Variant Calling

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Tomas Cumlin; [2022]
    Nyckelord :Next-generation sequencing; Variant calling; Clinical sequencing; Substitution error; Cancer sequencing; Error rate; substitution; Somatic mutation;

    Sammanfattning : Massive parallel sequencing (NGS) is useful in detecting and later classifying somatic driver mutations in cancer tumours. False-positive variants occur in the NGS workflow and they may be mistaken for low frequency somatic cancer mutations in a patient sample. LÄS MER

  5. 4. A mixed clinicopathological and molecular proxy of homologous recombination deficiency in triple negative breast cancer

    Master-uppsats, Lunds universitet/Examensarbeten i bioinformatik

    Författare :Elise Walford; [2021]
    Nyckelord :Biology and Life Sciences;

    Sammanfattning : Clinical models are increasingly employed in medical science as either diagnostic or prognostic aids. Machine-learning methods are able to draw links in large data that can be used to predict patient risk and allow more informed decisions regarding treatment and medication intervention. LÄS MER

  7. 5. Efficient Generation of Mutants for Testing Execution Time

    Magister-uppsats, Mälardalens högskola/Akademin för innovation, design och teknik

    Författare :Mohammed Abusamaan; Mohammed Abuayyash; [2020]
    Nyckelord :Targeted Mutation; Mutation Testing; Software Engineering; Mutants; WCET; Testing;

    Sammanfattning : In this thesis, we specifically focus on testing non-functional proprieties. We target the Worst-Case Execution Time (WCET), which is very important for real-time tasks. This thesis applies the concept of targeted mutation, where the mutations are applied to the parts of the code that are most likely to significantly affect the execution time. LÄS MER