Sökning: "germline"

Visar resultat 1 - 5 av 13 uppsatser innehållade ordet germline.

  1. 1. Investigating the expression and function of RNA-binding protein FUBL-1 in C. elegans

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Védís Mist Eyju Agnadóttir; [2023]
    Nyckelord :;

    Sammanfattning : RNA interference (RNAi) is an important mechanism of gene silencing in Caenorhabditis elegans, in which short RNAs direct sequence-specific silencing of gene expression mediated by Argonaute proteins. RNAi in C. LÄS MER

  3. 2. Implementing ExomeDepth with a variant filter as a CNV-calling tool for germline clinical diagnostic testing

    Magister-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Alice Krysén; [2022]
    Nyckelord :;

    Sammanfattning : Copy number variations (CNVs) cover approximately 4.9 - 9.5% of the human genome. CNVs are involved in both the development of disease and evolutionary adaptions. LÄS MER

  4. 3. CRISPR AND THETREATMENT/EN DISTINCTION : On Vagueness, Borderline Cases and Germline Genome Editing

    Kandidat-uppsats, Umeå universitet/Institutionen för idé- och samhällsstudier

    Författare :Ellen Svensson; [2021]
    Nyckelord :CRISPR; Treatment; Enhancement; Vagueness; Borderline cases; Slippery slope; Germline genome editing; GGE; Gene editing; Distinction; Ethics; Radical Enhancement; Human Nature; Eugenics;

    Sammanfattning : In this thesis, I argue that the treatment/enhancement distinction that is central to the ethical debate concerning germline genome editing and CRISPR is too vague to be ethically and normatively guiding. The problem of vagueness is twofold, being both a semantic and epistemic issue. LÄS MER

  5. 4. Visualizing neuronal cell sub-populations using novel transgenic zebrafish lines.

    Master-uppsats, Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Författare :Aikaterini Zafeiriou; [2021]
    Nyckelord :Zebrafish; CRISPR Cas9; locomotion; confocal microscopy; immunohistochemistry;

    Sammanfattning : Zebrafish is a frequently used model organism with an array of transgenic lines that have been used indevelopmental and physiological studies. We aim to generate novel transgenic zebrafish reporter lines to study subpopulations of spinal neurons in vivo. LÄS MER

  7. 5. Development and validation of bioinformatic methods for GRC assembly and annotation

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Roberto Rossini; [2020]
    Nyckelord :GRC; Germline restricted chromosome; kFish; assembly;

    Sammanfattning : This thesis presents the work done during my master degree projects under the supervision of Alexander Suh and Francisco J. Ruiz-Ruano. My work focused on the development of in-silico methods to improve the assembly of the Germline Restricted Chromosome (GRC) of songbirds, more specifically that of zebra finch. LÄS MER