Avancerad sökning
Hittade 3 uppsatser som matchar ovanstående sökkriterier.
1. Automated pipeline for processing fluorescence calcium imaging microscopy data and electrophysiological measurements from 3D brain organoids
Master-uppsats, Lunds universitet/Examensarbeten i bioinformatikSammanfattning : Motivation: 3D brain organoids are biological models of human brain development from which a rich body of data can be extracted that allows for insights about neuronal dynamics. Several tools, such as fluorescence calcium imaging microscopy and electrophysiological recordings are being used to assess how 3D brain organoid dynamics recapitulate what is known from the human brain. LÄS MER
2. Building predictive unbound brain-to-plasma concentration ratio (Kp,uu,brain) models
Master-uppsats, Lunds universitet/Examensarbeten i bioinformatikSammanfattning : Abstract The blood-brain barrier (BBB) constitutes a dynamic membrane primarily evolved to protect the brain from exposure to harmful xenobiotics. The distribution of synthesized drugs across the blood-brain barrier (BBB) is a vital parameter to consider in drug discovery projects involving a central nervous system (CNS) target, since the molecules should be capable of crossing the major hurdle, BBB. LÄS MER
3. Molecular topology, a novel descriptor for compound quality assessment
Master-uppsats, Lunds universitet/Examensarbeten i bioinformatikSammanfattning : Abstract The pharmaceutical industry is currently facing a high clinical attrition rate. In order to prevent the late-stage clinical failure, many investigations on compound quality and drug-likeness of compounds have been carried out. It has been widely accepted that molecular size and lipophilicity plays an important role in compound quality. LÄS MER
