Sökning: "unbound fraction"

Hittade 3 uppsatser innehållade orden unbound fraction.

  1. 1. Development and validation of an ultrafiltration-UHPLC-MS/MS method for the quantification of unbound Beta-Lactam antibiotics cefotaxime, piperacillin, cloxacillin and flucloxacillin in plasma

    Master-uppsats, KTH/Tillämpad fysikalisk kemi

    Författare :Leona Clarin; [2020]
    Nyckelord :Unbound concentration; free concentration; ultrafiltration; LC-MS MS; cefotaxime; flucloxacillin; cloxacillin; piperacillin; Fri fraktion; ultrafiltrering; LC-MS MS; cefotaxim; flukloxacillin; kloxacillin; piperacillin;

    Sammanfattning : Infections in critically ill patients are a problem for the healthcare system and at any one time, 70 % of all intensive care unit (ICU) patients are treated with antibiotics. Antibiotics bind toproteins in the blood, but only unbound drug can diffuse over capillary membranes and bindto the targeted receptor. LÄS MER

  3. 2. Development and validation of an ultrafiltration-UHPLC-MS/MS method for the quantification of unbound Beta-Lactam antibiotics cefotaxime, piperacillin, cloxacillin and flucloxacillin in plasma

    Master-uppsats, KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Författare :Leona Clarin; [2020]
    Nyckelord :unbound; LC-MS MS; beta-lactam; antibiotics; ultrafiltration; proteinbindning; koncentration; antibiotika; beta-laktam; ultrafiltrering;

    Sammanfattning : Kritiskt sjuka patienter med infektioner är en börda för sjukvården och 70 % av alla patienter på intensivvårdsavdelningar är ordinerade antibiotika. Antibiotika binder till proteiner i blodet, men enbart den icke-proteinbundna (fria) fraktionen kan diffundera över kapillära membran och binda till receptorer. LÄS MER

  4. 3. Building predictive unbound brain-to-plasma concentration ratio (Kp,uu,brain) models

    Master-uppsats, Lunds universitet/Examensarbeten i bioinformatik

    Författare :Srinidhi Varadharajan; [2014]
    Nyckelord :Biology and Life Sciences;

    Sammanfattning : Abstract The blood-brain barrier (BBB) constitutes a dynamic membrane primarily evolved to protect the brain from exposure to harmful xenobiotics. The distribution of synthesized drugs across the blood-brain barrier (BBB) is a vital parameter to consider in drug discovery projects involving a central nervous system (CNS) target, since the molecules should be capable of crossing the major hurdle, BBB. LÄS MER