Sökning: "Active pharmaceutical ingredient"

Visar resultat 6 - 10 av 25 uppsatser innehållade orden Active pharmaceutical ingredient.

1. 6. Optimization of two high-performance size-exclusion chromatography methods with diode-array detection for protein quantification and purity assessment

   Master-uppsats, Lunds universitet/Centrum för analys och syntes

   Författare :Camilla Lane; [2023]
   Nyckelord :Method qualification; Protein concentration; Protein Purity; High Performance Size exclusion chromatography; Quality control; Analytical chemistry; Biology and Life Sciences;

   Sammanfattning : Background: There is a need to develop methods of determining concentration and purity for two new affinity ligands, protein T and protein H, in order to ensure the quality of an industrial production of said proteins. Aims: To develop a High Performance Size Exclusion Chromatography, HPSEC, method to determine concentration and purity of protein T and to improve an existing HPSEC method for concentration and purity determination of protein H that show selectivity, display linearity between peak area and injection amount and give repeatable results. LÄS MER

3. 7. The impact of addition of force control agent in adhesive mixtures : Effect of magnesium stearates on flowability and aerosolization properties

   Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

   Författare :Moa Erlandsson; [2023]
   Nyckelord :;

   Sammanfattning : When drugs need to be delivered to the respiratory system dry powder inhalers (DPIs) are often used. The powders in DPIs often consists of a micronized active pharmaceutical ingredient (API) that is adhered to a larger carrier particle forming an adhesive mixture. LÄS MER

4. 8. The effect of lactose fines, magnesium stearate, choice of mixer and mixing process on the performance of adhesive mixtures for inhalation

   Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

   Författare :Gabriela Ponce Aparicio; [2023]
   Nyckelord :High shear mixing; low shear mixing; lactose fines; coating agent; budesonide; mixing energy; dry powder inhaler; carrier-based formulations; mixing time; adhesive mixtures; pharmaceutical technology; Technology and Engineering;

   Sammanfattning : Dry powder inhaler (DPI) formulation is a major area of interest since they are employed by the healthcare system to treat relevant chronic diseases like asthma. Previous research has established that the manufacturing process and formulation composition are key for the active pharmaceutical ingredient to reach the lungs and achieve therapeutic effects. LÄS MER

5. 9. Storage period optimization of a viscous nasal spray suspension

   Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

   Författare :Lili Zsófia Domián; [2023]
   Nyckelord :Rhinocort; viscosity; rheology; thixotropy; pharmaceutical technology; Technology and Engineering;

   Sammanfattning : The number of people suffering from the unpleasant symptoms of allergic rhinitis is increasing due to environmental and other factors. This not only makes life difficult for the individual but also places a heavy burden on society, which is why treatment is needed. LÄS MER

7. 10. Phenol-Protein Solution Stability

   Magister-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

   Författare :Johan Sjölund; [2022]
   Nyckelord :Phenol; Protein; Proteins; Lysozyme; Betalactoglobulin; Trastuzumab; Lipase; GAZ; GA-Z; Palifermin; Titration; Probedrum; Pharmaceutical Technology; Chemistry;

   Sammanfattning : Phenol is a commonly used preservative in pharmaceutical protein solutions. It is compatible with most proteins but can cause aggregation and denaturation at higher concentrations or in more sensitive proteins. LÄS MER