Sökning: "Dose-response models"

Visar resultat 1 - 5 av 8 uppsatser innehållade orden Dose-response models.

  1. 1. Design and analysis of pre-clinical experiments using a method combining multiple comparisons and modeling techniques for dose-response studies

    Master-uppsats, Göteborgs universitet/Institutionen för matematiska vetenskaper

    Författare :Avijit Singh; [2021-04-20]
    Nyckelord :pharmacodynamic modeling; dose–response relationship; significance level; multiple comparison procedure; optimal design; MCPMod; dose finding study;

    Sammanfattning : Abstract. Identifying and estimating the dose-response relationship between a compound and a pharmacological endpoint of interest is one of the most important and difficult goals in the preclinical stage of pharmaceutical drug development. LÄS MER

  3. 2. Validation of a 3D culture model for toxicity studies in malignant and non-cancerous cells

    Master-uppsats, Lunds universitet/Institutionen för immunteknologi

    Författare :Kajsa Andreasson Dahlgren; [2021]
    Nyckelord :Dose-response; potency; in vitro; 2D model; 3D model; cancer; MEK inhibitor; trametinib; A549; LL47; Western blot; Biology and Life Sciences;

    Sammanfattning : Cancer is a widespread and commonly fatal disease in constant need of new treatments. Traditionally, new pharmaceuticals have been tested in 2D models. This is not ideal, as 2D environments do not reflect the in vivo milieu of the cells. LÄS MER

  4. 3. Comparison of Multiple Models for Diabetes Using Model Averaging

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaci

    Författare :Alex Al-Mashat; [2021]
    Nyckelord :pharmacometrics; population pharmacokinetics; pop-pk; pop-PK diabetes; model averaging; MA; cross-validation; cv; CV; akaike information criterion; Akaike; aic; AIC; MPG; mpg; FPG; fpg; FPI; fpi; HbA1c; hba1c; farmakometri; populationsfarmakokinetik; diabetes; model averaging; MA; cross-validation; cv; CV; akaike; Akaike; aic; AIC; MPG; mpg; FPG; fpg; FPI; fpi; HbA1c; hba1c;

    Sammanfattning : Pharmacometrics is widely used in drug development. Models are developed to describe pharmacological measurements with data gathered from a clinical trial. The information can then be applied to, for instance, safely establish dose-response relationships of a substance. LÄS MER

  5. 4. Active dose selection and dose-response modeling for quantitative high-throughput screening (qHTS)

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Cancerfarmakologi och beräkningsmedicin

    Författare :Joel Ås; [2016]
    Nyckelord :;

    Sammanfattning : This master thesis studies the potential benefit of iterative selection of the concentrations evaluated when building mathematical dose-response curves (and response surfaces when there are two drugs) using experimental measurements. The reference alternative is to use a standard two-fold dilution series or ten-fold dilution series measured in replicates. LÄS MER

  7. 5. Robust Optimization for Uncertain Radiobiological Parameters in Inverse Dose Planning

    Master-uppsats, KTH/Optimeringslära och systemteori

    Författare :Jennie Falk; [2015]
    Nyckelord :;

    Sammanfattning : Cancer is a common cause of death worldwide with radiotherapy as one of the most used treatments. Radiation treatment plans are normally optimized using constraints on the maximum dose to tumours and minimum dose to surrounding healthy structures. LÄS MER