Sökning: "G-CSF"

Hittade 4 uppsatser innehållade ordet G-CSF.

  1. 1. A Molecular Dynamics Simulation Study of the Protein Stability of Reteplase in Formulation with Various Excipients during Freeze-Drying Processing

    Uppsats för yrkesexamina på avancerad nivå, Lunds universitet/Biofysikalisk kemi

    Författare :Gabriella Björkengren; [2021]
    Nyckelord :Biophysical chemistry; protein stability; molecular dynamics simulation; Chemistry;

    Sammanfattning : The purpose of this project was to investigate protein stabilization by formulation excipients during the process of freeze-drying using Molecular Dynamics (MD) simulation. A recombinant therapeutic protein, Reteplase, was used as a model and the study focused on a comparative analysis of two excipients, arginine and tranexamic acid (TXA), as included in commercially available formulations of Reteplase. LÄS MER

  3. 2. Optimization of Calcium-Dependent Affinity Ligands for Protein Purification

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Linnea Öst; [2021]
    Nyckelord :Protein purification; Protein A; calcium-dependent; scFv; G-CSF; multimerization; mild elution; ZCa;

    Sammanfattning : With an expanding life-science sector and growing production of recombinant proteins, the need for efficient downstream processing is increasing. Certain proteins are sensitive to the harsh conditions often used in protein purification, such as low pH, which can result in aggregation and denaturation. LÄS MER

  4. 3. Läkemedelsinducerad agranulocytos

    Kandidat-uppsats, Umeå universitet/Farmakologi

    Författare :Fatema Shaker; [2017]
    Nyckelord :Läkemedelsutlöst agranulocytos; risk; tyreostatika; granulocytkolonistimulerande faktor G-CSF ; mekanism;

    Sammanfattning : .... LÄS MER

  5. 4. Perfusion MRI: Non-Linear Stochastic Regularization for Deconvolution of Model-Free Arterial Spin Labelling Data

    Master-uppsats, Lunds universitet/Sjukhusfysikerutbildningen

    Författare :Andre Ahlgren; [2011]
    Nyckelord :MRI; Medicine and Health Sciences;

    Sammanfattning : Introduction: Arterial spin labelling (ASL) is a non-invasive magnetic resonance imaging (MRI) technique for assessment of perfusion. ASL uses magnetically labelled blood water as a diffusible endogenous tracer to measure the perfusion of brain tissue, i.e. the cerebral blood flow (CBF). LÄS MER