Sökning: "Genome editing"

Visar resultat 1 - 5 av 22 uppsatser innehållade orden Genome editing.

  1. 1. Fitnesskomponenter hos honor av Drosophila melanogaster : Med alternativa alleler av en potentiell sexuellt antagonistisk gen

    Kandidat-uppsats, Karlstads universitet/Fakulteten för hälsa, natur- och teknikvetenskap (from 2013)

    Författare :Maja Högström; [2023]
    Nyckelord :Drosophila melanogaster; fruit fly; intralocus sexual conflict; antagonistic genes; Drosophila melanogaster; bananfluga; antagonistiska gener; sexuellt antagonistiska gener;

    Sammanfattning : Anisogami och sexuella konflikter kan vara grunden till flera fall av könslig dimorfism. Intralokus sexuell konflikt uppstår när alleler vid ett genetiskt lokus har en antagonistisk effekt på fitness hos hanar och honor. Helgenomstudier har pekat ut flera sexuellt antagonistiska kandidatgener hos Drosophila melanogaster. LÄS MER

  3. 2. Establishing novel approaches for assessing safety of genome-editing-based therapeutics

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Noorul Shaheen Sheikh Farid; [2023]
    Nyckelord :;

    Sammanfattning : Genome editing based medicines are a new therapeutic modality being developed. They show great promise for a spectrum of genetic diseases lacking conventional treatment strategies. A major obstacle that prevents such therapies to reach the clinic is their safety. LÄS MER

  4. 3. Compounds screening for the identification of novel drug to improve the Knock in efficiency mediated by CRISPR-Cas9

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Evangelia Anagnostou; [2023]
    Nyckelord :Genome editing; Knock in; HDR; CRISPR-Cas9; screening; NHEJ;

    Sammanfattning : Genome editing is an exciting field that allows for the precise modification of an organism's DNA. One of the most advanced tools in this area is CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated protein 9), which creates a DSB (Double-strand break) at a specific location in the genome. LÄS MER

  5. 4. mRNA-based pharmaceuticals : A literature study based on current knowledge of mRNA

    Kandidat-uppsats, Uppsala universitet/Institutionen för kemi - Ångström

    Författare :Alicia Andersson; Isabella Åkerfeldt; Amanda Borgenstam; Ellinor Olsson; Adam Nyström; [2022]
    Nyckelord :mRNA-pharmaceuticals; mRNA therapies; mRNA vaccines; mRNA components; mRNA design; and mRNA applications.;

    Sammanfattning : This literature study provides a comprehensive overview of the current knowledge of mRNA-based pharmaceuticals, technologies and applications.  mRNA-based pharmaceuticals have newly been bought into focus as a potential brand-new drug class and many believe that it has the potential to transform areas of medicine. LÄS MER

  7. 5. Exploration of the hereditary cause of sex ratio distortion in horses

    Master-uppsats, SLU/Dept. of Animal Breeding and Genetics

    Författare :Susan Ott; [2021]
    Nyckelord :Sex ratio; horse; selfish genetic elements; meiotic drive; Icelandic horse; Standardbred horse; Coldblooded trotters; heritability; Trivers-Willard hypothesis; pedigree data;

    Sammanfattning : Even sex ratios are seen as evolutionarily stable and are maintained by a selection against a skewed sex ratio. However, sometimes sex ratios at birth are skewed towards one sex. Reasons for this phenomenon are often unknown. LÄS MER