Sökning: "alpha-synuclein"

Visar resultat 1 - 5 av 6 uppsatser innehållade ordet alpha-synuclein.

  1. 1. Effect of DNAJB6 on α-synuclein amyloid fibril aggregation and dis-aggregation

    Uppsats för yrkesexamina på avancerad nivå, Lunds universitet/Biofysikalisk kemi

    Författare :Josef Getachew; [2023]
    Nyckelord :α-synuclein; alpha-synuclein; chaperones; DNAJB6; the unhappy chaperone; parkinsons disease; biophysical chemistry; biochemistry; Biology and Life Sciences; Chemistry; Technology and Engineering;

    Sammanfattning : Amyloid proteins are a group of proteins with the ability to form large fibrillar aggregates, identifiable by their cross-β core structure. These aggregates are linked to several different neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease and due to the growing rate of people diagnosed, there is a need to combat these diseases. LÄS MER

  3. 2. Affinity of Alpha-Synuclein and Lipid Vesicle Interaction

    Master-uppsats, Lunds universitet/Fasta tillståndets fysik; Lunds universitet/Fysiska institutionen

    Författare :Ahmed Masaada; [2019]
    Nyckelord :Physics and Astronomy;

    Sammanfattning : Alpha-synuclein is a protein involved in several neurodegenerative diseases, such as Parkinson’s, where it has been observed to form amyloid fibrils or Lewy bodies. However, how or to what extent alpha-synuclein is involved is not known. LÄS MER

  4. 3. A calorimetric study of α-synuclein fibril formation & peptide induced vesicle leakage

    Kandidat-uppsats, Lunds universitet/Kemiska institutionen

    Författare :Emil Axell; [2017]
    Nyckelord :Differential Scanning Calorimetry; ITC; Isothermal Titration Calorimetry; Parkinson; α-synuclein; Alpha synuclein; DSC; Melittin; Vesicles; biochemistry; biokemi; Chemistry;

    Sammanfattning : The small protein α-synuclein is strongly associated with Parkinson’s disease. This protein is found in inclusion bodies, named lewy bodies inside neurons of people suffering from the disease. α-synuclein is very abundant in the human brain, and its normal function is still elusive and unclear. LÄS MER

  5. 4. Lipid Bilayers on Planes and in Micropipettes - Two model systems to study binding of DivIVA to flat and negatively curved membranes

    Master-uppsats, Lunds universitet/Fysikalisk kemi; Lunds universitet/Fysiska institutionen

    Författare :Elisabeth Baumann; [2016]
    Nyckelord :supported lipid bilayer; DivIVA; curvature; TIRF; FRAP; epifluorescence microscopy; micropipette; model system; Physics and Astronomy;

    Sammanfattning : The aim of this thesis work was to form and characterize model systems of cell membranes on planar supports and in micropipettes. Firstly, supported lipid bilayers (SLBs) were formed on glass slides after an existing experimental procedure. LÄS MER

  7. 5. Quantification of alpha-synuclein in cerebrospinal fluid

    Master-uppsats, Institutionen för fysik, kemi och biologi; Tekniska högskolan

    Författare :Björn Kronander; [2012]
    Nyckelord :alpha-synuclein parkinson cerebrospinal fluid biomarker;

    Sammanfattning : To date there is no accepted clinical diagnostic test for Parkinson's disease (PD) based on biochemical analyses of blood or cerebrospinal uid. Currently, diagnosis, measurement of disease progression and response to therapeutic intervention are based on clinical observation, but the rst neuronal dysfunction precede the earliest recognition of symptom by at least 5 - 10 years. LÄS MER