Sökning: "genome sequencing"

Visar resultat 1 - 5 av 139 uppsatser innehållade orden genome sequencing.

1. 1. Multiple-Emitter Super-resolution Imaging using the Alternating Descent Conditional Gradient Method

   Kandidat-uppsats, Lunds universitet/Beräkningsbiologi och biologisk fysik - Genomgår omorganisation; Lunds universitet/Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation

   Författare :Dolev Illouz; [2023]
   Nyckelord :super-resolution; alternating descent conditional gradient method; ADCG; multiple-emitter localization; nanoscale imaging; single molecule tracking; Physics and Astronomy;

   Sammanfattning : This thesis examines the state-of-the-art 2D super-resolution technique alternating descent conditional gradient (ADCG) method's ability to accurately localize fluorophores in diffraction-limited single molecule images (SMI) and analyze the impact of pre-processing and post-processing modules on ADCG's fluorophore localization. A synthetic dataset obtained from the 2013 Grand Challenge localization microscopy and a temporally linked dataset obtained from an unpublished set of Optical DNA mapping experiments performed by Jonathan Jeffet at the NanoBioPhotonix Lab at Tel-Aviv University were initially segmented to extract their noise parameters. LÄS MER

3. 2. Establishing novel approaches for assessing safety of genome-editing-based therapeutics

   Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

   Författare :Noorul Shaheen Sheikh Farid; [2023]
   Nyckelord :;

   Sammanfattning : Genome editing based medicines are a new therapeutic modality being developed. They show great promise for a spectrum of genetic diseases lacking conventional treatment strategies. A major obstacle that prevents such therapies to reach the clinic is their safety. LÄS MER

4. 3. Exploring the genetic cause of myotonic dystrophy in horses

   Master-uppsats, SLU/Dept. of Animal Breeding and Genetics

   Författare :Thomas Simon; [2023]
   Nyckelord :genetics; bioinformatics; myotonic dystrophy; horses; variant analysis;

   Sammanfattning : Myotonic Dystrophy (MD) is an inherited neuromuscular disorder that leads to a wide range of clinical signs including stiffness, abnormal muscle relaxation, and muscle atrophy or hypertrophy. Affected muscles develop a prolonged contracture in response to percussion of the muscle and show waxing and waning complex repetitive discharges in electromyography (EMG). LÄS MER

5. 4. The gut microbiome and nausea in pregnancy

   Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

   Författare :Clàudia González Valdivia; [2023]
   Nyckelord :Bioinformatics; Microbiome; Metagenomics; Genome analysis; Genetics;

   Sammanfattning : Nausea and vomiting are among the most common symptoms of early pregnancy. Its most extreme form Hyperemesis gravidarum often requires hospitalization and has been linked as a risk factor of perinatal depression. LÄS MER

7. 5. SubKluster: Novel method to bin scaffolds from cereal genomes into subgenomes using substring frequency analysis

   Master-uppsats, Lunds universitet/Examensarbeten i bioinformatik

   Författare :Victor Kalbskopf; [2023]
   Nyckelord :Biology and Life Sciences;

   Sammanfattning : The genome of the Belinda variety of the hexaploid oat (Avena sativa) has recently been sequenced and assembled. This project aims to improve the assembly by clustering the thousands of scaffolds into their three ancestral subgenomes using Principle Component Analysis (PCA) of kmer and repeat-element frequencies. LÄS MER